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  1. Content type: Research

    Multiple sclerosis (MS) impacts approximately 400,000 in the United States and is the leading cause of disability among young to middle aged people in the developed world. Characteristic of this disease, myeli...

    Authors: T. A. Olmstead, P. A. Chiarelli, D. J. Griggs, A. M. McClintic, A. N. Myroniv and P. D. Mourad

    Citation: Journal of Therapeutic Ultrasound 2018 6:11

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  2. Content type: Case study

    Magnetic resonance guided high-intensity focused ultrasound (MR-HIFU) therapy is not feasible in all patients with uterine fibroids because of limiting anatomical factors such as scar tissue, bowel loops or ot...

    Authors: Teija Sainio, Gaber Komar, Jani Saunavaara, Visa Suomi, Kirsi Joronen, Antti Perheentupa, Antti Viitala and Roberto Blanco Sequeiros

    Citation: Journal of Therapeutic Ultrasound 2018 6:10

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  3. Content type: Research

    Hyperthermia therapy (HT) has shown to be an effective adjuvant to radiation, chemotherapy, and immunotherapy. In order to be safe and effective, delivery of HT requires maintenance of target tissue temperatur...

    Authors: Eugene Ozhinsky, Vasant A. Salgaonkar, Chris J. Diederich and Viola Rieke

    Citation: Journal of Therapeutic Ultrasound 2018 6:7

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  4. Content type: Research

    With the expanding applications of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU), there is an urgent need for a convenient, reliable, and fast acoustic pressure field measurement method...

    Authors: Satya V. V. N. Kothapalli, Ari Partanen, Lifei Zhu, Michael B. Altman, H. Michael Gach, Dennis E. Hallahan and Hong Chen

    Citation: Journal of Therapeutic Ultrasound 2018 6:5

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  5. Content type: Research

    The development of imaging technologies and breast cancer screening allowed early detection of breast cancers. High-intensity focused ultrasound (HIFU) is a non-invasive cancer treatment, but the success of HI...

    Authors: Kohei Okita, Ryuta Narumi, Takashi Azuma, Hidemi Furusawa, Junichi Shidooka, Shu Takagi and Yoichiro Matsumoto

    Citation: Journal of Therapeutic Ultrasound 2018 6:4

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  6. Content type: Meeting report

    The Winter School on Therapeutic Ultrasound held its biennial meeting at the Ecole de Physique des Houches in Les Houches, France from March 26-31, 2017. The program brought together a globally and scientifica...

    Authors: Natasha D. Sheybani

    Citation: Journal of Therapeutic Ultrasound 2018 6:3

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  7. Content type: Research

    Prostate cancer is frequently treated using external beam radiation therapy (EBRT). Prior to therapy, the prostate is commonly implanted with a small number of permanent fiducial markers used to monitor the po...

    Authors: Marina Bakaric, Eleanor Martin, Panayiotis S. Georgiou, Benjamin T. Cox, Heather Payne and Bradley E. Treeby

    Citation: Journal of Therapeutic Ultrasound 2018 6:1

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  8. Content type: Research

    Our previous studies have indicated that ultrasound can stimulate the release of insulin from pancreatic beta cells, providing a potential novel treatment for type 2 diabetes. The purpose of this study was to ...

    Authors: Ivan Suarez Castellanos, Tania Singh, Bogdan Balteanu, Diti Chatterjee Bhowmick, Aleksandar Jeremic and Vesna Zderic

    Citation: Journal of Therapeutic Ultrasound 2017 5:30

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  9. Content type: Research

    Ultrasound myocardial cavitation enabled treatment (MCET) is an image-guided method for tissue reduction. In this study, a strategy of fractionated (multiple) treatments was tested for efficacy.

    Authors: Douglas L. Miller, Xiaofang Lu, Chunyan Dou, Yiying I. Zhu, Mario L. Fabiilli, Gabe E. Owens and Oliver D. Kripfgans

    Citation: Journal of Therapeutic Ultrasound 2017 5:29

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  10. Content type: Study protocol

    TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety...

    Authors: Paul C. Lyon, Lucy F. Griffiths, Jenni Lee, Daniel Chung, Robert Carlisle, Feng Wu, Mark R. Middleton, Fergus V. Gleeson and Constantin C. Coussios

    Citation: Journal of Therapeutic Ultrasound 2017 5:28

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  11. Content type: Research

    During lengthy magnetic resonance-guided high intensity focused ultrasound (MRg-HIFU) thermal ablations in abdominal organs, the therapeutic work-flow is frequently hampered by various types of physiological m...

    Authors: Cornel Zachiu, Baudouin Denis de Senneville, Ivan D. Dmitriev, Chrit T. W. Moonen and Mario Ries

    Citation: Journal of Therapeutic Ultrasound 2017 5:27

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  12. Content type: Review

    MRI guided focused ultrasound is an emerging technique that uses acoustic energy to noninvasively treat intracranial disorders. At high frequencies, it can be used to raise tissue temperatures and ablate discr...

    Authors: Ying Meng, Suganth Suppiah, Karim Mithani, Benjamin Solomon, Michael L. Schwartz and Nir Lipsman

    Citation: Journal of Therapeutic Ultrasound 2017 5:26

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  13. Content type: Research

    The purpose of these clinical studies was to validate a Tissue Change Monitoring (TCM) algorithm in vivo. TCM is a quantitative tool for the real-time assessment of HIFU dose. TCM provides quantitative analysi...

    Authors: Narendra T. Sanghvi, Wo-Hsing Chen, Roy Carlson, Clint Weis, Ralf Seip, Toyoaki Uchida and Michael Marberger

    Citation: Journal of Therapeutic Ultrasound 2017 5:24

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  14. Content type: Research

    To retrospectively compare the treatment success, therapeutic efficacy, and adverse effects of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment for uterine fibroid patients with ...

    Authors: Bilgin Keserci and Nguyen Minh Duc

    Citation: Journal of Therapeutic Ultrasound 2017 5:22

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  15. Content type: Research

    High intensity focused ultrasound (HIFU) has gained clinical interest as a non-invasive local tumour therapy in many organs. In addition, it has been shown that lung cancer can be targeted by HIFU using One-Lu...

    Authors: Frank Wolfram, Georg Dietrich, Carsten Boltze, Klaus Vitold Jenderka and Thomas Günther Lesser

    Citation: Journal of Therapeutic Ultrasound 2017 5:21

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  16. Content type: Research

    Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) ablation is in development for minimally invasive treatment of breast cancer. Cost-effectiveness has not been assessed yet. An early health...

    Authors: Floortje M. Knuttel, Sèvrin E. M. Huijsse, Talitha L. Feenstra, Chrit T. W. Moonen, Maurice A. A. J. van den Bosch, Erik Buskens, Marcel J. W. Greuter and Geertruida H. de Bock

    Citation: Journal of Therapeutic Ultrasound 2017 5:23

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  17. Content type: Research

    Focused ultrasound (FUS) is entering clinical routine as a treatment option. Currently, no clinically available FUS treatment system features automated respiratory motion compensation. The required quality sta...

    Authors: Michael Schwenke, Jan Strehlow, Daniel Demedts, Sabrina Haase, Diego Barrios Romero, Sven Rothlübbers, Caroline von Dresky, Stephan Zidowitz, Joachim Georgii, Senay Mihcin, Mario Bezzi, Christine Tanner, Giora Sat, Yoav Levy, Jürgen Jenne, Matthias Günther…

    Citation: Journal of Therapeutic Ultrasound 2017 5:20

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  18. Content type: Research

    Dysfunction of the Sacroiliac Joint (SIJ) is one of the key sources of low back pain. For prolonged pain relief, some patients undergo fluoroscopic guided radio-frequency (RF) ablation of SIJ, during which a n...

    Authors: Elena A. Kaye, Majid Maybody, Sebastien Monette, Stephen B. Solomon and Amitabh Gulati

    Citation: Journal of Therapeutic Ultrasound 2017 5:17

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  19. Content type: Research

    Past catheter-based and focused ultrasound renal denervation studies have indicated that procedure efficacy is related to the number of ablations performed or the amount of energy used for the ablation. This s...

    Authors: Jill Shea, Joshua de Bever, Eugene Kholmovski, Hannah Beal, J. Rock Hadley, Emilee Minalga, Mohamed E. Salama, Nassir F. Marrouche and Allison Payne

    Citation: Journal of Therapeutic Ultrasound 2017 5:16

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  20. Content type: Research

    Volumetric thermometry with fine spatiotemporal resolution is desirable to monitor MR-guided focused ultrasound (MRgFUS) procedures in the brain, but requires some form of accelerated imaging. Accelerated MR t...

    Authors: Pooja Gaur, Beat Werner, Xue Feng, Samuel W. Fielden, Craig H. Meyer and William A. Grissom

    Citation: Journal of Therapeutic Ultrasound 2017 5:13

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  21. Content type: Research

    The goal of this study was to theoretically investigate the feasibility of intraductal and transgastric approaches to ultrasound-based thermal therapy of pancreatic tumors, and to evaluate possible treatment s...

    Authors: Serena J. Scott, Matthew S. Adams, Vasant Salgaonkar, F. Graham Sommer and Chris J. Diederich

    Citation: Journal of Therapeutic Ultrasound 2017 5:10

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  22. Content type: Research

    Mild-hyperthermia therapy (40–45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulat...

    Authors: Vandiver Chaplin and Charles F. Caskey

    Citation: Journal of Therapeutic Ultrasound 2017 5:12

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  23. Content type: Research

    Pancreatic adenocarcinoma is currently the fourth-leading cause of cancer-related death. Up to 60–90% of patients with advanced disease suffer cancer-related pain, severely impacting their quality of life. Cur...

    Authors: Susan Dababou, Cristina Marrocchio, Jarrett Rosenberg, Rachelle Bitton, Kim Butts Pauly, Alessandro Napoli, Joo Ha Hwang and Pejman Ghanouni

    Citation: Journal of Therapeutic Ultrasound 2017 5:9

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  24. Content type: Meeting abstracts

    Authors: Brian Fowlkes, Pejman Ghanouni, Narendra Sanghvi, Constantin Coussios, Paul C. Lyon, Michael Gray, Christophoros Mannaris, Marie de Saint Victor, Eleanor Stride, Robin Cleveland, Robert Carlisle, Feng Wu, Mark Middleton, Fergus Gleeson, Jean-Franҫois Aubry, Kim Butts Pauly…

    Citation: Journal of Therapeutic Ultrasound 2017 5(Suppl 1):15

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    This article is part of a Supplement: Volume 5 Supplement 1

  25. Content type: Research

    Safety analyses of transcranial therapeutic ultrasound procedures require knowledge of the dependence of the rupture probability and rupture time upon sonication parameters. As previous vessel-rupture studies ...

    Authors: Yeonho Kim, Marjan Nabili, Priyanka Acharya, Asis Lopez and Matthew R. Myers

    Citation: Journal of Therapeutic Ultrasound 2017 5:5

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  26. Content type: Research

    There is growing evidence that maximal surgical resection of primary intrinsic brain tumours is beneficial, both by improving progression free and overall survival and also by facilitating postoperative chemot...

    Authors: Sophie J. Camp, Vasileios Apostolopoulos, Vasileios Raptopoulos, Amrish Mehta, Kevin O’Neill, Mohammed Awad, Babar Vaqas, David Peterson, Federico Roncaroli and Dipankar Nandi

    Citation: Journal of Therapeutic Ultrasound 2017 5:2

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  27. Content type: Research

    Magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids is rapidly gaining popularity as a treatment modality. This procedure is generally uncomfortable, painful, and requ...

    Authors: Hermanus H. B. Vaessen, F. M. Knuttel, J. M. M. van Breugel, M. E. Ikink, J. M. Dieleman, M. A. A. J. van den Bosch and J. T. A. Knape

    Citation: Journal of Therapeutic Ultrasound 2017 5:8

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  28. Content type: Research

    One goal of therapeutic ultrasound is enabling heat generation in tissue. Ultrasound application protocols typically neglect these processes of absorption and backscatter/reflection at the skin/fat, fat/muscle...

    Authors: Thaís Pionório Omena, Aldo José Fontes-Pereira, Rejane Medeiros Costa, Ricardo Jorge Simões, Marco Antônio von Krüger and Wagner Coelho de Albuquerque Pereira

    Citation: Journal of Therapeutic Ultrasound 2017 5:3

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  29. Content type: Research

    Phase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and ...

    Authors: Samantha M. Fix, Anthony Novell, Yeoheung Yun, Paul A. Dayton and Christopher B. Arena

    Citation: Journal of Therapeutic Ultrasound 2017 5:7

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  30. Content type: Research

    A novel magnetic resonance imaging (MRI)-conditional coupling system was developed that accommodates a focused ultrasound (FUS) transducer. With this coupling system, the transducer can access targets from top...

    Authors: Marinos Yiannakou, George Menikou, Christos Yiallouras and Christakis Damianou

    Citation: Journal of Therapeutic Ultrasound 2017 5:6

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  31. Content type: Research

    Non-invasive high-intensity focused ultrasound (HIFU) can be used to treat a variety of disorders, including those in the brain. However, the differences in acoustic properties between the skull and the surrou...

    Authors: Scott Almquist, Dennis L. Parker and Douglas A. Christensen

    Citation: Journal of Therapeutic Ultrasound 2016 4:30

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  32. Content type: Study protocol

    A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM)...

    Authors: Giovanni Borasi, Alan Nahum, Margarethus M. Paulides, Gibin Powathil, Giorgio Russo, Laura Fariselli, Debora Lamia, Roberta Cirincione, Giusi Irma Forte, Cristian Borrazzo, Barbara Caccia, Elisabetta di Castro, Silvia Pozzi and Maria Carla Gilardi

    Citation: Journal of Therapeutic Ultrasound 2016 4:32

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  33. Content type: Research

    Ultrasound therapies are promising, non-invasive applications with potential to significantly improve, e.g. cancer therapies like viro- or immunotherapy or surgical applications. However, a crucial step toward...

    Authors: Tina A. Fuhrmann, Olga Georg, Julian Haller, Klaus-V. Jenderka and Volker Wilkens

    Citation: Journal of Therapeutic Ultrasound 2016 4:28

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  34. Content type: Meeting abstracts

    Authors: Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna, Amelia Hargrove, Punit Agrawal, Barbara Changizi, Eric Bourekas…

    Citation: Journal of Therapeutic Ultrasound 2016 4(Suppl 1):31

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    This article is part of a Supplement: Volume 4 Supplement 1

  35. Content type: Research

    Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjac...

    Authors: Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug and Viola Rieke

    Citation: Journal of Therapeutic Ultrasound 2016 4:26

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  36. Content type: Research

    Uterine fibroids are the most common benign tumor in women, and surgical intervention is still the main fibroid treatment. Patient demands have encouraged development of less-invasive methods such as high-inte...

    Authors: Rui Chen, Bilgin Keserci, Hui Bi, Xiaobing Han, Xiaoying Wang, Wenpei Bai, Yueling Wang, Xuedong Yang, Jian Yang, Juan Wei, Minna Seppälä, Antti Viitala and Qinping Liao

    Citation: Journal of Therapeutic Ultrasound 2016 4:27

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  37. Content type: Research

    Low-intensity pulsed ultrasound (LIPUS) has presented good results in the healing of chronic wounds. The objective of this study was to compare the effect of LIPUS on the viability of transverse rectus abdomin...

    Authors: Fernanda Luiza de Almeida Albuquerque, Lais Mara Siqueira das Neves and Elaine Caldeira de Oliveira Guirro

    Citation: Journal of Therapeutic Ultrasound 2016 4:25

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  38. Content type: Research

    Low-intensity physiotherapeutic ultrasound has been used in physical therapy clinics; however, there remain some scientific issues regarding the bone-healing process. The objective of this study was to investi...

    Authors: Aldo José Fontes-Pereira, Marcio Amorim, Fernanda Catelani, Daniel Patterson Matusin, Paulo Rosa, Douglas Magno Guimarães, Marco Antônio von Krüger and Wagner Coelho de Albuquerque Pereira

    Citation: Journal of Therapeutic Ultrasound 2016 4:24

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