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  1. Research

    A focused ultrasound treatment system for moving targets (part I): generic system design and in-silico first-stage evaluation

    Focused ultrasound (FUS) is entering clinical routine as a treatment option. Currently, no clinically available FUS treatment system features automated respiratory motion compensation. The required quality sta...

    Michael Schwenke, Jan Strehlow, Daniel Demedts, Sabrina Haase, Diego Barrios Romero, Sven Rothlübbers, Caroline von Dresky, Stephan Zidowitz, Joachim Georgii, Senay Mihcin, Mario Bezzi, Christine Tanner, Giora Sat, Yoav Levy, Jürgen Jenne, Matthias Günther…

    Journal of Therapeutic Ultrasound 2017 5:20

    Published on: 24 July 2017

  2. Research

    Ablation of the sacroiliac joint using MR-guided high intensity focused ultrasound: a preliminary experiment in a swine model

    Dysfunction of the Sacroiliac Joint (SIJ) is one of the key sources of low back pain. For prolonged pain relief, some patients undergo fluoroscopic guided radio-frequency (RF) ablation of SIJ, during which a n...

    Elena A. Kaye, Majid Maybody, Sebastien Monette, Stephen B. Solomon and Amitabh Gulati

    Journal of Therapeutic Ultrasound 2017 5:17

    Published on: 26 June 2017

  3. Research

    Effect of applied energy in renal sympathetic denervation with magnetic resonance guided focused ultrasound in a porcine model

    Past catheter-based and focused ultrasound renal denervation studies have indicated that procedure efficacy is related to the number of ablations performed or the amount of energy used for the ablation. This s...

    Jill Shea, Joshua de Bever, Eugene Kholmovski, Hannah Beal, J. Rock Hadley, Emilee Minalga, Mohamed E. Salama, Nassir F. Marrouche and Allison Payne

    Journal of Therapeutic Ultrasound 2017 5:16

    Published on: 12 June 2017

  4. Research

    Spatially-segmented undersampled MRI temperature reconstruction for transcranial MR-guided focused ultrasound

    Volumetric thermometry with fine spatiotemporal resolution is desirable to monitor MR-guided focused ultrasound (MRgFUS) procedures in the brain, but requires some form of accelerated imaging. Accelerated MR t...

    Pooja Gaur, Beat Werner, Xue Feng, Samuel W. Fielden, Craig H. Meyer and William A. Grissom

    Journal of Therapeutic Ultrasound 2017 5:13

    Published on: 30 May 2017

  5. Research

    Theoretical investigation of transgastric and intraductal approaches for ultrasound-based thermal therapy of the pancreas

    The goal of this study was to theoretically investigate the feasibility of intraductal and transgastric approaches to ultrasound-based thermal therapy of pancreatic tumors, and to evaluate possible treatment s...

    Serena J. Scott, Matthew S. Adams, Vasant Salgaonkar, F. Graham Sommer and Chris J. Diederich

    Journal of Therapeutic Ultrasound 2017 5:10

    Published on: 3 May 2017

  6. Research

    Multi-focal HIFU reduces cavitation in mild-hyperthermia

    Mild-hyperthermia therapy (40–45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulat...

    Vandiver Chaplin and Charles F. Caskey

    Journal of Therapeutic Ultrasound 2017 5:12

    Published on: 13 April 2017

  7. Research

    A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound

    Pancreatic adenocarcinoma is currently the fourth-leading cause of cancer-related death. Up to 60–90% of patients with advanced disease suffer cancer-related pain, severely impacting their quality of life. Cur...

    Susan Dababou, Cristina Marrocchio, Jarrett Rosenberg, Rachelle Bitton, Kim Butts Pauly, Alessandro Napoli, Joo Ha Hwang and Pejman Ghanouni

    Journal of Therapeutic Ultrasound 2017 5:9

    Published on: 1 April 2017

  8. Meeting abstracts

    International Society for Therapeutic Ultrasound Conference 2016

    Brian Fowlkes, Pejman Ghanouni, Narendra Sanghvi, Constantin Coussios, Paul C. Lyon, Michael Gray, Christophoros Mannaris, Marie de Saint Victor, Eleanor Stride, Robin Cleveland, Robert Carlisle, Feng Wu, Mark Middleton, Fergus Gleeson, Jean-Franҫois Aubry, Kim Butts Pauly…

    Journal of Therapeutic Ultrasound 2017 5(Suppl 1):15

    Published on: 17 March 2017

    This article is part of a Supplement: Volume 5 Supplement 1

  9. Research

    Microvessel rupture induced by high-intensity therapeutic ultrasound—a study of parameter sensitivity in a simple in vivo model

    Safety analyses of transcranial therapeutic ultrasound procedures require knowledge of the dependence of the rupture probability and rupture time upon sonication parameters. As previous vessel-rupture studies ...

    Yeonho Kim, Marjan Nabili, Priyanka Acharya, Asis Lopez and Matthew R. Myers

    Journal of Therapeutic Ultrasound 2017 5:5

    Published on: 2 March 2017

  10. Research

    Objective image analysis of real-time three-dimensional intraoperative ultrasound for intrinsic brain tumour surgery

    There is growing evidence that maximal surgical resection of primary intrinsic brain tumours is beneficial, both by improving progression free and overall survival and also by facilitating postoperative chemot...

    Sophie J. Camp, Vasileios Apostolopoulos, Vasileios Raptopoulos, Amrish Mehta, Kevin O’Neill, Mohammed Awad, Babar Vaqas, David Peterson, Federico Roncaroli and Dipankar Nandi

    Journal of Therapeutic Ultrasound 2017 5:2

    Published on: 16 February 2017

  11. Research

    Moderate-to-deep sedation technique, using propofol and ketamine, allowing synchronised breathing for magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids: a pilot study

    Magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids is rapidly gaining popularity as a treatment modality. This procedure is generally uncomfortable, painful, and requ...

    Hermanus H. B. Vaessen, F. M. Knuttel, J. M. M. van Breugel, M. E. Ikink, J. M. Dieleman, M. A. A. J. van den Bosch and J. T. A. Knape

    Journal of Therapeutic Ultrasound 2017 5:8

    Published on: 9 February 2017

  12. Case study

    MRgFUS for desmoid tumors within the thigh: early clinical experiences

    Desmoid tumors are benign but locally aggressive non-malignant tumors derived from fibroblasts. Surgery, chemotherapy, and radiation therapy have been the mainstay of treatment, but recurrence is common and si...

    Matthew D. Bucknor and Viola Rieke

    Journal of Therapeutic Ultrasound 2017 5:4

    Published on: 3 February 2017

  13. Research

    Why we should care about soft tissue interfaces when applying ultrasonic diathermy: an experimental and computer simulation study

    One goal of therapeutic ultrasound is enabling heat generation in tissue. Ultrasound application protocols typically neglect these processes of absorption and backscatter/reflection at the skin/fat, fat/muscle...

    Thaís Pionório Omena, Aldo José Fontes-Pereira, Rejane Medeiros Costa, Ricardo Jorge Simões, Marco Antônio von Krüger and Wagner Coelho de Albuquerque Pereira

    Journal of Therapeutic Ultrasound 2017 5:3

    Published on: 27 January 2017

  14. Research

    An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro

    Phase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and ...

    Samantha M. Fix, Anthony Novell, Yeoheung Yun, Paul A. Dayton and Christopher B. Arena

    Journal of Therapeutic Ultrasound 2017 5:7

    Published on: 24 January 2017

  15. Study protocol

    Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

    A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM)...

    Giovanni Borasi, Alan Nahum, Margarethus M. Paulides, Gibin Powathil, Giorgio Russo, Laura Fariselli, Debora Lamia, Roberta Cirincione, Giusi Irma Forte, Cristian Borrazzo, Barbara Caccia, Elisabetta di Castro, Silvia Pozzi and Maria Carla Gilardi

    Journal of Therapeutic Ultrasound 2016 4:32

    Published on: 8 December 2016

  16. Research

    Uncertainty estimation for temperature measurement with diagnostic ultrasound

    Ultrasound therapies are promising, non-invasive applications with potential to significantly improve, e.g. cancer therapies like viro- or immunotherapy or surgical applications. However, a crucial step toward...

    Tina A. Fuhrmann, Olga Georg, Julian Haller, Klaus-V. Jenderka and Volker Wilkens

    Journal of Therapeutic Ultrasound 2016 4:28

    Published on: 1 December 2016

  17. Meeting abstracts

    5th International Symposium on Focused Ultrasound

    Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna, Amelia Hargrove, Punit Agrawal, Barbara Changizi, Eric Bourekas…

    Journal of Therapeutic Ultrasound 2016 4(Suppl 1):31

    Published on: 21 November 2016

    This article is part of a Supplement: Volume 4 Supplement 1

  18. Research

    T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound

    Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjac...

    Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug and Viola Rieke

    Journal of Therapeutic Ultrasound 2016 4:26

    Published on: 17 November 2016

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