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  1. Content type: Research

    A major challenge in using magnetic resonance temperature imaging (MRTI) to monitor focused ultrasound (FUS) applications is achieving high spatio-temporal resolution over a large field of view (FOV). This is ...

    Authors: Henrik Odéen, Scott Almquist, Joshua de Bever, Douglas A. Christensen and Dennis L. Parker

    Citation: Journal of Therapeutic Ultrasound 2016 4:23

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  2. Content type: Research

    MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and bl...

    Authors: Megan E. Poorman, Vandiver L. Chaplin, Ken Wilkens, Mary D. Dockery, Todd D. Giorgio, William A. Grissom and Charles F. Caskey

    Citation: Journal of Therapeutic Ultrasound 2016 4:22

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    The Erratum to this article has been published in Journal of Therapeutic Ultrasound 2016 4:29

  3. Content type: Research

    Skin function is dependent on its biomechanical characteristics, resistance, malleability, and elasticity. Therapeutic ultrasound may increase cutaneous malleability thus and optimize the rehabilitation proces...

    Authors: Lígia Brancalion Catapani, Adriana da Costa Gonçalves, Nathalia Morano Candeloro, Lídia Aparecida Rossi and Elaine Caldeira de Oliveira Guirro

    Citation: Journal of Therapeutic Ultrasound 2016 4:21

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  4. Content type: Case study

    Abdominal scars pose a challenge in magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) therapies, limiting patient selection and increasing the risk of skin burns. Especially, scars arising ...

    Authors: Ying Zhu, Bilgin Keserci, Antti Viitala, Juan Wei, Xuedong Yang and Xiaoying Wang

    Citation: Journal of Therapeutic Ultrasound 2016 4:20

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  5. Content type: Research

    Previous studies demonstrated both pre-clinically and clinically the feasibility of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablations in the liver. To overcome the associated prob...

    Authors: Johanna M. M. van Breugel, Joost W. Wijlemans, Hermanus H. B. Vaessen, Martijn de Greef, Chrit T. W. Moonen, Maurice A. A. J. van den Bosch and Mario G. Ries

    Citation: Journal of Therapeutic Ultrasound 2016 4:19

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  6. Content type: Review

    Diagnostic ultrasound (DUS) pressures have the ability to induce inertial cavitation (IC) of systemically administered microbubbles; this bioeffect has many diagnostic and therapeutic implications in cardiovas...

    Authors: Thomas R. Porter, Songita A. Choudhury and Feng Xie

    Citation: Journal of Therapeutic Ultrasound 2016 4:18

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  7. Content type: Review

    Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive an...

    Authors: Michael J. Temple, Adam C. Waspe, Joao G. Amaral, Alessandro Napoli, Suzanne LeBlang, Pejman Ghanouni, Matthew D. Bucknor, Fiona Campbell and James M. Drake

    Citation: Journal of Therapeutic Ultrasound 2016 4:16

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  8. Content type: Review

    We present here biophysical models to gain deeper insights into how an acoustic stimulus might influence or modulate neuronal activity. There is clear evidence that neural activity is not only associated with ...

    Authors: Elisabetta Sassaroli and Natalia Vykhodtseva

    Citation: Journal of Therapeutic Ultrasound 2016 4:17

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  9. Content type: Research

    A noninvasive technique to monitor thermal lesion formation is necessary to ensure the accuracy and safety of high-intensity focused ultrasound (HIFU) treatment. The purpose of this study is to ultrasonically ...

    Authors: Shin Yoshizawa, Keiko Matsuura, Ryo Takagi, Mariko Yamamoto and Shin-ichiro Umemura

    Citation: Journal of Therapeutic Ultrasound 2016 4:15

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  10. Content type: Research

    MR-guided focused ultrasound (MRgFUS) might be a very safe and effective minimally invasive technique to treat facet joint pain caused by arthritis and other degenerative changes. However, there are still safe...

    Authors: Roland Krug, Loi Do, Viola Rieke, Mark W. Wilson and Maythem Saeed

    Citation: Journal of Therapeutic Ultrasound 2016 4:14

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  11. Content type: Research

    Bioheat models have been proposed to predict heat distribution in multilayered biological tissues after therapeutic ultrasound (TUS) stimulation. However, evidence on its therapeutic benefit is still controver...

    Authors: Gabriella Sellani, Dalila Fernandes, Abigail Nahari, Melissa Fabrício de Oliveira, Christiana Valois, Wagner C. A. Pereira and Christiano B. Machado

    Citation: Journal of Therapeutic Ultrasound 2016 4:13

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  12. Content type: Study protocol

    Radiotherapy is a critical component of the multidisciplinary management of cancers of the head and neck. It may comprise the primary curative treatment modality or is used in an adjuvant setting to improve lo...

    Authors: Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen and Danny Enepekides

    Citation: Journal of Therapeutic Ultrasound 2016 4:12

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  13. Content type: Research

    To improve understanding of shockwave therapy mechanisms, in vitro experiments are conducted and the correlation between cell reaction and shockwave parameters like the maximum pressure or energy density is st...

    Authors: Kristin Dietz-Laursonn, Rainer Beckmann, Siegfried Ginter, Klaus Radermacher and Matías de la Fuente

    Citation: Journal of Therapeutic Ultrasound 2016 4:10

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  14. Content type: Research

    The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ult...

    Authors: Mie K. Lam, Chris Oerlemans, Martijn Froeling, Roel Deckers, Angelique D. Barten-Van Rijbroek, Max A. Viergever, Chrit T. W. Moonen, Clemens Bos and Lambertus W. Bartels

    Citation: Journal of Therapeutic Ultrasound 2016 4:9

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  15. Content type: Research

    The purpose of this study is to evaluate and report the feasibility, safety, and initial outcomes of patients with limited localized prostate cancer treated using a trans-rectal magnetic resonance image-guided...

    Authors: Bertram Yuh, An Liu, Robert Beatty, Alexander Jung and Jeffrey Y. C. Wong

    Citation: Journal of Therapeutic Ultrasound 2016 4:8

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  16. Content type: Review

    Cerebral vasospasm is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH), causing delayed neurological deficits in as many as one third of cases. Existing therapy targets i...

    Authors: Robert H. Bonow, John R. Silber, Dieter R. Enzmann, Norman J. Beauchamp, Richard G. Ellenbogen and Pierre D. Mourad

    Citation: Journal of Therapeutic Ultrasound 2016 4:6

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  17. Content type: Research

    Already in the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat pati...

    Authors: Marc N. Gallay, David Moser, Franziska Rossi, Payam Pourtehrani, Anouk E. Magara, Milek Kowalski, Alexander Arnold and Daniel Jeanmonod

    Citation: Journal of Therapeutic Ultrasound 2016 4:5

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  18. Content type: Research

    The study aims to investigate different ground plane segmentation designs of an ultrasound transducer to reduce gradient field induced eddy currents and the associated geometric distortion and temperature map ...

    Authors: Silke M. Lechner-Greite, Nicolas Hehn, Beat Werner, Eyal Zadicario, Matthew Tarasek and Desmond Yeo

    Citation: Journal of Therapeutic Ultrasound 2016 4:4

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  19. Content type: Research

    Initial catheter-based renal sympathetic denervation (RSD) studies demonstrated promising results in showing a significant reduction of blood pressure, while recent data were less successful. As an alternative...

    Authors: Matthias Koopmann, Jill Shea, Eugene Kholmovski, Joshua de Bever, Emilee Minalga, Matthew Holbrook, Robb Merrill, J. Rock Hadley, Theophilus Owan, Mohamed E. Salama, Nassir F. Marrouche and Allison Payne

    Citation: Journal of Therapeutic Ultrasound 2016 4:3

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  20. Content type: Case study

    Therapy of choice for symptomatic vascular malformations consists of surgery, sclerotherapy, or embolization. However, these techniques are invasive with possible complications and require hospitalization. We ...

    Authors: Johanna M. M. van Breugel, Robbert J. Nijenhuis, Mario G. Ries, Raechel J. Toorop, Evert-Jan P. A. Vonken, Joost W. Wijlemans and Maurice A. A. J. van den Bosch

    Citation: Journal of Therapeutic Ultrasound 2015 3:23

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  21. Content type: Research

    Focused ultrasound combined with microbubble injection is capable of locally and transiently enhancing the permeability of the blood-brain barrier (BBB). Magnetic resonance imaging (MRI) guidance enables to pl...

    Authors: Rémi Magnin, Fabien Rabusseau, Frédéric Salabartan, Sébastien Mériaux, Jean-François Aubry, Denis Le Bihan, Erik Dumont and Benoit Larrat

    Citation: Journal of Therapeutic Ultrasound 2015 3:22

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  22. Content type: Case study

    High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurre...

    Authors: M. Abel, H. Ahmed, E. Leen, E. Park, M. Chen, H. Wasan, P. Price, L. Monzon, W. Gedroyc and P. Abel

    Citation: Journal of Therapeutic Ultrasound 2015 3:21

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  23. Content type: Research

    A device was devised which aimed to reduce the time and expertise required to perform sonoporation on adherent cell cultures. This prototype device was used to examine the superficial effect of bath temperatur...

    Authors: Jonathan Kivinen, Melissa Togtema, Gregor Mulzer, Joshua Choi, Ingeborg Zehbe, Laura Curiel and Samuel Pichardo

    Citation: Journal of Therapeutic Ultrasound 2015 3:19

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  24. Content type: Research

    Myocardial cavitation-enabled therapy (MCET) has been proposed as a means to achieve minimally invasive myocardial reduction using ultrasound to produce scattered microlesions by cavitating contrast agent micr...

    Authors: Yiying I. Zhu, Douglas L. Miller, Chunyan Dou, Xiaofang Lu and Oliver D. Kripfgans

    Citation: Journal of Therapeutic Ultrasound 2015 3:18

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  25. Content type: Research

    Deep Bleeder Acoustic Coagulation (DBAC) is an ultrasound image-guided high-intensity focused ultrasound (HIFU) method proposed to automatically detect and localize (D&L) and treat deep, bleeding, combat wound...

    Authors: K. Michael Sekins, Stephen R. Barnes, Liexiang Fan, Jerry D. Hopple, Stephen J. Hsu, John Kook, Chi-Yin Lee, Caroline Maleke, Xiaozheng (Jenny) Zeng, Romain Moreau-Gobard, Alexis Ahiekpor-Dravi, Gareth Funka-Lea, John Eaton, Keith Wong, Scott Keneman, Stuart B. Mitchell…

    Citation: Journal of Therapeutic Ultrasound 2015 3:17

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  26. Content type: Research

    Bleeding from limb injuries is a leading cause of death on the battlefield, with deep wounds being least accessible. High-intensity focused ultrasound (HIFU) has been shown capable of coagulation of bleeding (...

    Authors: K. Michael Sekins, Stephen R. Barnes, Liexiang Fan, Jerry D. Hopple, Stephen J. Hsu, John Kook, Chi-Yin Lee, Caroline Maleke, A R Ramachandran, Xiaozheng (Jenny) Zeng, Romain Moreau-Gobard, Alexis Ahiekpor-Dravi, Gareth Funka-Lea, Stuart B. Mitchell, Barbrina Dunmire, John C. Kucewicz…

    Citation: Journal of Therapeutic Ultrasound 2015 3:16

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  27. Content type: Research

    Near-field heating is a potential problem in focused ultrasound treatments, as it can result in thermal injury to skin, subcutaneous fat, and other tissues. Our goals were to determine if T2-based temperature ...

    Authors: Eugene Ozhinsky, Maureen P. Kohi, Pejman Ghanouni and Viola Rieke

    Citation: Journal of Therapeutic Ultrasound 2015 3:15

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  28. Content type: Research

    Thermal and mechanical high intensity focused ultrasound (HIFU) ablation techniques are in development for non-invasive treatment of cancer. However, knowledge of in vivo histopathologic and immunologic reacti...

    Authors: Martijn Hoogenboom, Martinus J. van Amerongen, Dylan C. Eikelenboom, Melissa Wassink, Martijn H. den Brok, Christina Hulsbergen-van de Kaa, Erik Dumont, Gosse J. Adema, Arend Heerschap and Jurgen J. Fütterer

    Citation: Journal of Therapeutic Ultrasound 2015 3:14

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  29. Content type: Research

    Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a promising technique for palliative treatment of bone pain. In this study, the effects of MR-HIFU ablation on bone mechanics and modeli...

    Authors: Sin Yuin Yeo, Andrés J. Arias Moreno, Bert van Rietbergen, Natalie D. ter Hoeve, Paul J. van Diest and Holger Grüll

    Citation: Journal of Therapeutic Ultrasound 2015 3:13

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  30. Content type: Research

    Ultrasound induces mechanical vibration and heat, causing differentiation and proliferation in osteoblasts. All known in vitro evaluations of ultrasound are, however, performed with longitudinal ultrasound waves....

    Authors: James Macione, Daniel Long, Sterling Nesbitt, Scott Wentzell, Hiroki Yokota, Vaibhav Pandit and Shiva Kotha

    Citation: Journal of Therapeutic Ultrasound 2015 3:12

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  31. Content type: Research

    Transcranial focused ultrasound (tcFUS) is an attractive noninvasive modality for neurosurgical interventions. The presence of the skull, however, compromises the efficiency of tcFUS therapy, as its heterogene...

    Authors: Adamos Kyriakou, Esra Neufeld, Beat Werner, Gábor Székely and Niels Kuster

    Citation: Journal of Therapeutic Ultrasound 2015 3:11

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  32. Content type: Poster presentation

    Authors: Zhiyuan Xu, Carissa Carlson, John Snell, Matt Eames, Arik Hananel, M Beatriz Lopes, Prashant Raghavan, Cheng-Chia Lee, Chun-Po Yen, David Schlesinger, Neal Kassell, Jean-Francois Aubry and Jason Sheehan

    Citation: Journal of Therapeutic Ultrasound 2015 3(Suppl 1):P41

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    This article is part of a Supplement: Volume 3 Supplement 1