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  1. Study protocol

    Fast and high temperature hyperthermia coupled with radiotherapy as a possible new treatment for glioblastoma

    A new transcranial focused ultrasound device has been developed that can induce hyperthermia in a large tissue volume. The purpose of this work is to investigate theoretically how glioblastoma multiforme (GBM)...

    Giovanni Borasi, Alan Nahum, Margarethus M. Paulides, Gibin Powathil, Giorgio Russo, Laura Fariselli, Debora Lamia, Roberta Cirincione, Giusi Irma Forte, Cristian Borrazzo, Barbara Caccia, Elisabetta di Castro, Silvia Pozzi and Maria Carla Gilardi

    Journal of Therapeutic Ultrasound 2016 4:32

    Published on: 8 December 2016

  2. Research

    Uncertainty estimation for temperature measurement with diagnostic ultrasound

    Ultrasound therapies are promising, non-invasive applications with potential to significantly improve, e.g. cancer therapies like viro- or immunotherapy or surgical applications. However, a crucial step toward...

    Tina A. Fuhrmann, Olga Georg, Julian Haller, Klaus-V. Jenderka and Volker Wilkens

    Journal of Therapeutic Ultrasound 2016 4:28

    Published on: 1 December 2016

  3. Meeting abstracts

    5th International Symposium on Focused Ultrasound

    Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna, Amelia Hargrove, Punit Agrawal, Barbara Changizi, Eric Bourekas…

    Journal of Therapeutic Ultrasound 2016 4(Suppl 1):31

    Published on: 21 November 2016

    This article is part of a Supplement: Volume 4 Supplement 1

  4. Research

    T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound

    Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjac...

    Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug and Viola Rieke

    Journal of Therapeutic Ultrasound 2016 4:26

    Published on: 17 November 2016

  5. Research

    The safety and effectiveness of volumetric magnetic resonance-guided high-intensity focused ultrasound treatment of symptomatic uterine fibroids: early clinical experience in China

    Uterine fibroids are the most common benign tumor in women, and surgical intervention is still the main fibroid treatment. Patient demands have encouraged development of less-invasive methods such as high-inte...

    Rui Chen, Bilgin Keserci, Hui Bi, Xiaobing Han, Xiaoying Wang, Wenpei Bai, Yueling Wang, Xuedong Yang, Jian Yang, Juan Wei, Minna Seppälä, Antti Viitala and Qinping Liao

    Journal of Therapeutic Ultrasound 2016 4:27

    Published on: 3 November 2016

  6. Research

    Low-intensity pulsed ultrasound stimulation in different regions in the viability of myocutaneous flaps

    Low-intensity pulsed ultrasound (LIPUS) has presented good results in the healing of chronic wounds. The objective of this study was to compare the effect of LIPUS on the viability of transverse rectus abdomin...

    Fernanda Luiza de Almeida Albuquerque, Lais Mara Siqueira das Neves and Elaine Caldeira de Oliveira Guirro

    Journal of Therapeutic Ultrasound 2016 4:25

    Published on: 21 October 2016

  7. Research

    The influence of low-intensity physiotherapeutic ultrasound on the initial stage of bone healing in rats: an experimental and simulation study

    Low-intensity physiotherapeutic ultrasound has been used in physical therapy clinics; however, there remain some scientific issues regarding the bone-healing process. The objective of this study was to investi...

    Aldo José Fontes-Pereira, Marcio Amorim, Fernanda Catelani, Daniel Patterson Matusin, Paulo Rosa, Douglas Magno Guimarães, Marco Antônio von Krüger and Wagner Coelho de Albuquerque Pereira

    Journal of Therapeutic Ultrasound 2016 4:24

    Published on: 3 October 2016

  8. Research

    MR thermometry for focused ultrasound monitoring utilizing model predictive filtering and ultrasound beam modeling

    A major challenge in using magnetic resonance temperature imaging (MRTI) to monitor focused ultrasound (FUS) applications is achieving high spatio-temporal resolution over a large field of view (FOV). This is ...

    Henrik Odéen, Scott Almquist, Joshua de Bever, Douglas A. Christensen and Dennis L. Parker

    Journal of Therapeutic Ultrasound 2016 4:23

    Published on: 22 September 2016

  9. Research

    Open-source, small-animal magnetic resonance-guided focused ultrasound system

    MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and bl...

    Megan E. Poorman, Vandiver L. Chaplin, Ken Wilkens, Mary D. Dockery, Todd D. Giorgio, William A. Grissom and Charles F. Caskey

    Journal of Therapeutic Ultrasound 2016 4:22

    Published on: 5 September 2016

    The Erratum to this article has been published in Journal of Therapeutic Ultrasound 2016 4:29

  10. Research

    Influence of therapeutic ultrasound on the biomechanical characteristics of the skin

    Skin function is dependent on its biomechanical characteristics, resistance, malleability, and elasticity. Therapeutic ultrasound may increase cutaneous malleability thus and optimize the rehabilitation proces...

    Lígia Brancalion Catapani, Adriana da Costa Gonçalves, Nathalia Morano Candeloro, Lídia Aparecida Rossi and Elaine Caldeira de Oliveira Guirro

    Journal of Therapeutic Ultrasound 2016 4:21

    Published on: 17 August 2016

  11. Case study

    Volumetric MR-guided high-intensity focused ultrasound ablation to treat uterine fibroids through the abdominal scars using scar patch: a case report

    Abdominal scars pose a challenge in magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) therapies, limiting patient selection and increasing the risk of skin burns. Especially, scars arising ...

    Ying Zhu, Bilgin Keserci, Antti Viitala, Juan Wei, Xuedong Yang and Xiaoying Wang

    Journal of Therapeutic Ultrasound 2016 4:20

    Published on: 11 August 2016

  12. Research

    Procedural sedation and analgesia for respiratory-gated MR-HIFU in the liver: a feasibility study

    Previous studies demonstrated both pre-clinically and clinically the feasibility of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablations in the liver. To overcome the associated prob...

    Johanna M. M. van Breugel, Joost W. Wijlemans, Hermanus H. B. Vaessen, Martijn de Greef, Chrit T. W. Moonen, Maurice A. A. J. van den Bosch and Mario G. Ries

    Journal of Therapeutic Ultrasound 2016 4:19

    Published on: 29 July 2016

  13. Review

    Establishing a clinical service for the treatment of osteoid osteoma using magnetic resonance-guided focused ultrasound: overview and guidelines

    Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive an...

    Michael J. Temple, Adam C. Waspe, Joao G. Amaral, Alessandro Napoli, Suzanne LeBlang, Pejman Ghanouni, Matthew D. Bucknor, Fiona Campbell and James M. Drake

    Journal of Therapeutic Ultrasound 2016 4:16

    Published on: 20 May 2016

  14. Review

    Acoustic neuromodulation from a basic science prospective

    We present here biophysical models to gain deeper insights into how an acoustic stimulus might influence or modulate neuronal activity. There is clear evidence that neural activity is not only associated with ...

    Elisabetta Sassaroli and Natalia Vykhodtseva

    Journal of Therapeutic Ultrasound 2016 4:17

    Published on: 20 May 2016

  15. Research

    Detection of tissue coagulation by decorrelation of ultrasonic echo signals in cavitation-enhanced high-intensity focused ultrasound treatment

    A noninvasive technique to monitor thermal lesion formation is necessary to ensure the accuracy and safety of high-intensity focused ultrasound (HIFU) treatment. The purpose of this study is to ultrasonically ...

    Shin Yoshizawa, Keiko Matsuura, Ryo Takagi, Mariko Yamamoto and Shin-ichiro Umemura

    Journal of Therapeutic Ultrasound 2016 4:15

    Published on: 14 April 2016

  16. Research

    Assessing heating distribution by therapeutic ultrasound on bone phantoms and in vitro human samples using infrared thermography

    Bioheat models have been proposed to predict heat distribution in multilayered biological tissues after therapeutic ultrasound (TUS) stimulation. However, evidence on its therapeutic benefit is still controver...

    Gabriella Sellani, Dalila Fernandes, Abigail Nahari, Melissa Fabrício de Oliveira, Christiana Valois, Wagner C. A. Pereira and Christiano B. Machado

    Journal of Therapeutic Ultrasound 2016 4:13

    Published on: 5 April 2016

  17. Study protocol

    Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer—a pilot study

    Radiotherapy is a critical component of the multidisciplinary management of cancers of the head and neck. It may comprise the primary curative treatment modality or is used in an adjuvant setting to improve lo...

    Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen and Danny Enepekides

    Journal of Therapeutic Ultrasound 2016 4:12

    Published on: 2 April 2016

  18. Research

    Simulation of high-intensity focused ultrasound lesions in presence of boiling

    The lesions induced by high-intensity focused ultrasound (HIFU) thermal ablations are particularly difficult to simulate due to the complexity of the involved phenomena. In particular, boiling has a strong inf...

    Anthony Grisey, Sylvain Yon, Véronique Letort and Pauline Lafitte

    Journal of Therapeutic Ultrasound 2016 4:11

    Published on: 31 March 2016

  19. Research

    In-vitro cell treatment with focused shockwaves—influence of the experimental setup on the sound field and biological reaction

    To improve understanding of shockwave therapy mechanisms, in vitro experiments are conducted and the correlation between cell reaction and shockwave parameters like the maximum pressure or energy density is st...

    Kristin Dietz-Laursonn, Rainer Beckmann, Siegfried Ginter, Klaus Radermacher and Matías de la Fuente

    Journal of Therapeutic Ultrasound 2016 4:10

    Published on: 29 March 2016

  20. Research

    DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia

    The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ult...

    Mie K. Lam, Chris Oerlemans, Martijn Froeling, Roel Deckers, Angelique D. Barten-Van Rijbroek, Max A. Viergever, Chrit T. W. Moonen, Clemens Bos and Lambertus W. Bartels

    Journal of Therapeutic Ultrasound 2016 4:9

    Published on: 15 March 2016

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