Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
© Abel et al. 2015
Received: 29 April 2015
Accepted: 13 December 2015
Published: 18 December 2015
High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer.
A 38 year old woman receiving palliative chemotherapy for metastatic cervical adenocarcinoma was offered ablative treatment from an intracavitary trans-rectal HIFU device (Sonablate® 500). Pre-treatment symptoms included vaginal bleeding and discharge that were sufficient to impede her quality of life. No peri-procedural adverse events occurred. Symptoms resolved completely immediately post-procedure, reappeared at 7 days, increasing to pre-procedural levels by day 30.
Discussion and evaluation
This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Ethical approval had also been granted for the use of per-vaginal access if appropriate. This route, alone or in combination with the rectal route, may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations.
Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting.
High-intensity focused ultrasound (HIFU) is a non-invasive ablative treatment undergoing assessment for the treatment of benign and malignant disease with encouraging results. As technology advances and expertise accumulates, previous limiting factors including image-guidance (to accurately identify, target and monitor treatment) and lengthy therapeutic duration are being overcome. We describe the first reported intracavitary HIFU ablation for cervical cancer and determine that HIFU was feasible with demonstrable benefits.
Cervical cancer is the fourth most common cancer in women worldwide, with an estimated incidence of approximately 528,000 diagnoses and 266,000 deaths annually . It is potentially curable with a multi-modal approach that may include surgical excision, radiotherapy and cytotoxic chemotherapy. These therapeutic modalities may also delay progression and improve symptom control in advanced disease by palliating the unpleasant symptoms that include vaginal bleeding and/or discharge and intractable pain which can all impact negatively on quality of life.
HIFU conveys sonic energy to a defined target raising temperature to cause cell death by coagulative necrosis. Single-element devices consist of a curved transducer or incorporate lens to focus the energy at the target site. Ultrasonic waves from multi-element arrays converge at the treatment zone to cause ablation. Intervening tissues remain completely unharmed. Ablations are sequentially repeated in adjacent pathological tissue until the desired volume is destroyed. Guidance and monitoring of the treatment is through integrated ultrasound or magnetic resonance imaging .
HIFU devices are either intracavitary (minimally invasive through insertion into rectum or vagina) or extracorporeal (completely non-invasive). Intracavitary devices in the rectum have been extensively studied in thousands of men with prostate cancer , but to date, there has been no report of intracavitary HIFU in cervical cancer. Extracorporeal HIFU has been reported in one woman with cervical cancer successfully palliating local pain . In the past, lengthy treatment times and difficulties with accuracy of targeting have prevented wide-spread HIFU use, although current technology is rapidly improving to overcome these limitations.
UK National Ethics Committee approval (09/H0808/43) was granted for a pilot study to assess the feasibility, safety and efficacy of ultrasound-guided intracavitary HIFU in pelvic malignancy. Intracavitary HIFU treatment of a man with recurrent anastomotic colorectal cancer by our group resulted in symptomatic improvement within 24 h and radiological evidence of tumour necrosis at the target ablation site . We wanted to expand the potential of intracavitary HIFU therapy by, for the first time, determining feasibility for its use and ability to palliate, relieve pain and improve quality of life in advanced cervical cancer.
A 38 year old woman presenting with stage 1B2 histologically confirmed cervical adenocarcinoma and received primary chemotherapy/radiation followed by a brachytherapy boost. Ten months later, a recurrent local cervical mass and small volume nodal and pulmonary disease were identified radiologically. Palliative carboplatin and paclitaxel was given, but follow-up imaging identified continued disease progression and she remained with a persistent continuous, offensive smelling vaginal discharge requiring 7–8 pads daily and impacting her quality of life.
Chemotherapy was stopped 4 months prior to the ablation. Pre-HIFU treatment magnetic resonance imaging measured the cervical mass at approximately 7 × 4 × 4 cm, with invasion into adjacent fat planes and the lower myometrium. A computed tomography scan identified intralesional gas; although, a fistulous connection was ruled out on physical examination.
Fully informed, written consent was obtained prior to enrollment in this study. Under general anaesthetic, an intracavitary-guided HIFU device (Sonablate® 500, Sonacare Medical, Charlotte, NC, USA) currently utilised in the treatment of prostatic malignancy was passed into the rectum, as adequate alignment with the tumour could not be obtained trans-vaginally. The tumour and surrounding structures were visualised using integrated ultrasound imaging in sagittal and cross-axial planes, also providing treatment monitoring. Intralesional gas obscured the majority of the cranial portion of the lesion. Ultrasound energy cannot penetrate air so HIFU was targeted to an approximately 4 × 4 × 1 cm region at the inferior margin, the most likely area causing symptoms.
Discussion and evaluation
This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Rapid symptomatic benefit was achieved that has improved the quality of life. In contrast to radiotherapy, HIFU offers the additional benefit of no dose ceiling, allowing for repeated re-treatments if deemed appropriate on an individual basis.
Ethical approval had also been granted for the use of per-vaginal access if appropriate. Although considered for the procedure, insertion of the transducer into the vagina did not prove possible in this case. The device was not initially intended for gynaecological use, and it proved impossible to obtain satisfactory alignment to the target site as energy delivery is perpendicular to the transducer. This demonstrates the need to have HIFU transducers specifically tailored to individual indications. Alone or in combination with the rectal route, this may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations. Trans-vaginal ablations would also reduce the risk of post-procedural fistulae when compared to the trans-rectal approach, remove the possibility of skin burns seen with trans-abdominal treatments and lower the potential for damage to the healthy intervening tissue, by shortening the distance to the tumour.
In conclusion, further detailed studies are now required to fully assess safety and efficacy of HIFU, as well as dosimetry and development of a dedicated cervical/gynaecological probe design. As HIFU technology progresses, it could provide minimal toxicity with good relief of symptoms in patients who otherwise may have limited treatment options. In the future, HIFU could also become an established part of a multi-modal approach with curative intent in combination with current available therapy options to treat early stages of cervical and other gynaecological cancers.
This research was funded and supported by the National Institute for Health Research Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. We also acknowledge the support of the Nuada Medical Group in providing the equipment and personnel to perform the treatment, Dr Olwen Westerland for her contribution with response evaluation and Mr Victor Griffin for his help and advice during the procedure.
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