- Open Access
MR-guided focused ultrasound (MRgFUS) is effective for the distinct pattern of uterine fibroids seen in African-American women: data from phase III/IV, non-randomized, multicenter clinical trials
© Machtinger et al.; licensee BioMed Central Ltd. 2013
Received: 7 March 2013
Accepted: 4 October 2013
Published: 2 December 2013
Uterine fibroids are common among women at the reproductive age. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a novel and a conservative treatment for symptomatic cases. The aim of the study was to evaluate the efficacy of MRgFUS in African-American (AA) women compared with that in non-African-Americans (non-AA).
A single-armed phase IV study was conducted to establish the efficacy of treatment in AA women. Comparison of patient, fibroid, and treatment characteristics from this trial was compared with that of the previously published phase III trial. Both studies were approved by the IRB of each medical center.
Sixty-three AA and 59 non-AA women were treated with MRgFUS. Although AA women had a different pattern of disease, outcomes were similar in both groups. AA patients had a significant higher total number of fibroids compared with non-AA (median 6.0, interquartile range (IQR) 3.0–10.0 vs. 2.0, IQR 1.0–4.0, respectively, p < 0.001), although their total fibroid volume was significantly smaller (median 196.9 cm3, IQR 112.8–415.3 cm3 vs. 394.8 cm3, IQR 189.8–674.4 cm3, respectively, p < 0.001). AA women were younger compared with non-AA (mean ± SD 43.4 ± 5.1 vs. 46.3 ± 4.1 years of age, respectively, p = 0.001) when they presented for treatment. The rate of alternative treatments as well as fibroid-associated symptoms at follow-up time points (3, 6, 12, 24, and 36 months, period following MRgFUS treatment) did not differ according to race (p ≥ 0.62).
Despite differences in the pattern of fibroid disease, MRgFUS for uterine fibroids has a similar efficacy for AA women compared with non-AA women.
Uterine fibroids (leiomyomas or myomas) are an important healthcare issue, chiefly because of their frequency, associated morbidity, and their contribution to the rate of hysterectomy [1, 2]. Hysterectomy rates have declined in recent years in part due to the increasing array of minimally invasive alternatives to hysterectomy utilized for fibroid treatment including laparoscopic, hysteroscopic, and robotic myomectomy, endometrial ablation, uterine artery embolization (UAE), and magnetic resonance imaging (MRI)-guided focused ultrasound surgery (MRgFUS) as well as medical treatments [3, 4].
Uterine fibroids have significant health disparities for African-American (AA) women. Compared to other women, AA women have evidence of a more extensive pattern of fibroids and an earlier age of onset [5–8]. Genetic and biologic differences and differential growth rates may contribute to this racial disparity [9–12]. Despite this disparity, most studies of fibroid treatment have not reported the racial composition of enrolled participants, and studies that do report race often have few AA women .
MRgFUS is a Food and Drug Administration (FDA)-approved therapy for uterine leiomyomas that has been demonstrated in multiple reports to result in sustained treatment efficacy [14–20]. Early cohorts studied with this treatment were largely non-AA. In light of this reality, the primary purposes of this report were to evaluate the efficacy of MRgFUS in AA women relative to non-AA women and to determine the risk of adverse effects in the AA population. A secondary goal was to compare the pattern of fibroids in AA women enrolled in this study to that in other women enrolled in a previous clinical trial of MRgFUS that had the same enrollment criteria .
All data on AA women was collected as part of a phase IV, non-randomized, multicenter clinical trial designed to evaluate the safety and effectiveness of MRgFUS treatment in this specific high-risk population. Funding was provided by the device manufacturer (InSightec, Haifa, Israel), and the protocol was approved by each local institutional review board.
Women were treated between January 2005 and April 2006 at one of nine US clinical centers (Brigham and Women’s Hospital (BWH), Boston, MA, USA; Mayo Clinic, Rochester, MN, USA; Johns Hopkins Hospital, Baltimore, MD, USA; Radnet, Beverly Hills, CA, USA; Lahey, Burlington, MA, USA; Sightline, Houston, TX, USA; North Texas Uterine Fibroid Institute, Dallas, TX, USA; UMRI Boca Raton, FL, USA; and Virtua, Voorhees, NJ, USA). Because the enrollment criteria and treatment guidelines were identical to the earlier phase III multicenter clinical trial that led to the approval of this device, we utilized, as a comparison group, the data from this published clinical trial, whose patients were treated between April 2004 and January 2005 . Both clinical studies were approved by the IRB from each site.
The eligibility criteria for both trials have been previously described [14, 19, 21]. Briefly, subjects were premenopausal women in good general health, with symptomatic uterine fibroids, and who had no future childbearing plans.
Enrollment and screening
Patients seeking treatment for symptomatic uterine fibroids at one of nine US clinical centers were recruited through the gynecology and interventional radiology clinics. Flyers, posters, and local advertisements were used as recruitment tools. Eligible premenopausal women were asked to complete a validated Symptom Severity Score (SSS) from the uterine fibroid symptom and quality of life (UFS-QOL) questionnaire . The scores were transformed to create a transformed SSS, yielding a 0 to 100 point scale with higher scores indicating worse symptoms . Patients with SSS ≥ 41 (i.e., symptomatic uterine fibroids) were scheduled for a medical and gynecological assessment. If there were no significant medical contraindications for treatment (such as claustrophobia, severe hypertension, severe cerebrovascular disease, severe anemia, clotting disorders, or MR contraindications such as a cardiac pacemaker or other metallic devices, significant anterior abdominal scarring, high BMI, etc.), a pelvic MRI with intravenous gadolinium contrast was performed. MR images were analyzed to determine the number, size, and location of the fibroids. The enhancement patterns were also assessed on the post-contrast images. Screen failures were defined as women with symptomatic uterine fibroids who were interested in MRgFUS treatment but were not eligible due to one of the following: inadequate fibroid-associated symptoms, a medical history that was a contraindication for the treatment or imaging-associated reasons, or MR findings such as necrotic fibroid, extensive adenomyosis, multiple small (<3 cm) fibroids or single fibroids over 8 cm, and ones with large bowel loops interposed between the uterus and anterior abdominal wall.
The MRgFUS system (ExAblate 2000, InSightec, Haifa, Israel) integrates a standard 1.5-T MRI system (GE Medical Systems, Milwaukee, WI, USA) with the focused ultrasound treatment transducer housed in a water bath within the MR table. The MR imaging system, described in detail by Tempany et al.  and Stewart et al. , provides real-time feedback of the temperature changes by incorporating MR thermometry that uses sensitive imaging sequences during each sonication.
Patient preparation and treatment
Patient preparation has been previously described [20, 21, 23]. T2-weighted pelvic MR images were acquired and used for treatment planning. A region of treatment was defined within the fibroid on coronal imaging, and the number of spots (sonications) required to ablate this volume was calculated by the treatment software. Each sonication of focused ultrasound energy targeted an approximately 1-cm3 bean-shaped region. The sonication could be altered in power, frequency, diameter, and length to allow a great treatment volume as safely as possible using as few sonications as possible. Once planning was complete, low-energy test sonications were delivered to confirm correct sonication location. The power was then increased until the temperature-sensitive maps demonstrated a therapeutic thermal focus. Treatment failure was defined as a treatment in which fewer than ten sonications were performed.
At the end of the treatment, all patients underwent a contrast-enhanced T1-weighted MRI with IV administration of gadolinium (gadopentetate dimeglumine) and the resultant volume of non-enhancing tissue (non-perfused volume (NPV)) was measured. The NPV ratio to treated fibroid volume and NPV ratio to total fibroid volume were determined. In cases of patients who underwent two treatments, the NPV in the study was the total NPV achieved following the second MRgFUS treatment. The volume of treated fibroids was calculated from MRI images at 6 and 12 months after the treatment and compared with baseline.
The goal of treatment was to deliver the therapeutic sonications to as large fibroid area as possible, within the limitation of the clinical trial rules. All patients were treated according to similar guidelines, as outlined by Fennessy et al. . Treatment was limited to 50% of fibroid volume (except 33% if submucosal) or 150-cm3 maximum volumes. Maximum treatment time (from the first to the last sonication) was 180 min. In cases where a second treatment was deemed necessary, the second treatment was performed within a 14-day period.
Patient’s age, body mass index (BMI; kg/m2), race, total fibroid number, total fibroid volume (cm3), and volume of the treated fibroid(s) (cm3) were all prospectively collected. The patient’s race was self-defined, in keeping with the FDA’s recommendation, for the collection of race and ethnicity data in clinical trials . Patients were categorized as AA if it was their only declared race. All others were classified as non-AA. Patients were followed for up to 36 months after treatment. At 1 week and 3 months post-procedure, a phone interview was conducted, and at 6, 12, 24, and 36 months, a face-to-face interview was conducted to obtain an updated UFS-QOL SSS score. Also, at 6 and 12 months, a clinical evaluation and pelvic MRI were obtained to measure the volume of the treated fibroids.
All adverse events (AEs) were reported to the institutional review board and the US Food and Drug Administration as required. AEs were reported by the patients and then classified as serious or non-serious. Serious AEs were defined according to the Standard Code of Federal Regulation definitions for use of an investigational device . In cases of non-serious AEs, the reported complaints were further classified as important (lasting for >14 days) or not important (lasting for less than 14 days).
A subanalysis of the patients who were declared screen failures was conducted to compare the incidence and reasons for screen failure between AA and non-AA women using the data from the BWH site only (N = 39).
Statistical analyses were conducted using Statistical Analysis Software (SAS®) version 9.1 (SAS Institute, Inc., Cary, NC, USA). The Mann–Whitney-Wilcoxon test, a two-sided non-parametric test for two independent samples, was used to study unadjusted differences in baseline and treatment characteristics between the two racial groups. To compare each group’s trajectory of outcomes over time, the correlation between measures from the same individual must be accounted for. Therefore, a generalized estimating equation with a binomial distribution, a logit link, and compound symmetry covariance structure were used for dichotomous outcomes (alternative treatments), and mixed models with an unstructured covariance structure were used for continuous outcomes (QOL score, volume of treated fibroids). The models were adjusted for age and BMI.
A chi-square test was used to compare the proportion of AEs in each group. Among women with at least one AE, the numbers of AEs were compared using the Mann–Whitney-Wilcoxon test. Data are presented as mean ± SD for normally distributed variables and median and 25th–75th percentile (interquartile range (IQR)) for non-normally distributed variables.
Results and discussion
One hundred and thirty-seven women (mean age 44.8 ± 4.8, range 34–53 years) comprised our study population, all of whom had MRgFUS fibroid treatment. There were 64 patients included from the phase III comparison study, 62 of these were non-AA. The remaining 73 women were from the phase IV AA study. Fifteen patients were excluded from the final analysis: four were treatment failures, two AA patients who were treated as part of the phase III study, four patients had adenomyosis, and five patients had missing data (one patient had missing treatment MRI data, two patients had missing post-treatment data, and two patients had all imaging data missing).
Demographic and treatment characteristics of AA and non-AA women with symptomatic uterine fibroids treated by MRgFUS
AA (n= 63)
Non-AA (n= 59)
Body mass index (kg/m2)
Total number of fibroids
Total volume of fibroids (cm3)
Number of treated fibroids
Total volume of treated fibroids (cm3)
NPV ratio per total fibroid
NPV ratio per treated fibroid
A total of 128 AEs were recorded for the 65 patients in both studies: 63 AEs were reported among AA and 65 AEs were reported among non-AA. No serious AEs were reported. Non-AA patients reported more AEs following treatment compared with AA. Among the non-AA, 47/59 (79.7%) reported at least one AE vs. 18/63 (28.6%) reported in AA patients (p < 0.0001). Among those who reported AEs, there was no significant difference in the number of AEs per patient reported (2.0 ± 1.5 and 1.8 ± 1.0, non-AA vs. AA).
The common types of AEs reported for both groups were back/leg pain (21.9%), abdominal cramping (21.1%), urinary tract infection/irritation symptoms (11.7%), gastrointestinal complaints (11.7%), skin irritation (7.0%), and vaginal bleeding or discharge (6.3%).
Alternative treatments following MRgFUS treatment among AA and non-AA according to time of follow-up
Number of alternative treatments/total number of AA patients followed
Number of alternative treatments/total number of non-AA patients followed
3 months post-tx
6 months post-tx
12 months post-tx
24 months post-tx
36 months post-tx
Analysis of screen failures in a subpopulation
In a subanalysis, we compared the rates and the reasons for screen failures between AA women and non-AA women who sought MRgFUS treatment as a part of these clinical trials at a single institution. A total of 94 subjects provided informed consent for MRgFUS studies (40 AA and 54 non-AA) at the BWH site. Thirty-nine women (41.4%) failed to meet one or more enrollment criteria and were deemed screen failures.
AA women were more likely to be screen failures (52.5% AA vs. 33.3% non-AAs, p = 0.06). The reasons for screen failure differed significantly between groups. AA patients were more likely to fail the screening due to MRI findings that indicated that safe delivery of treatment was not possible, such as significant anterior abdominal wall scarring or bowel in the anterior ultrasound beam path (76.2% AA vs. 38.9% non-AA). However, they were less likely to fail screening due to inadequate fibroid-associated symptoms compared with the non-AA population (9.5% non-AA vs. 44.4% AA). Among the screen failures, AA patients had a higher mean number of fibroids at screening MRI (11.7 ± 11.8 AA vs. 4.4 ± 3.5 non-AA, p = 0.05) and their fibroid diameter was significantly smaller (median 2.4 cm, IQR 1.9–4.3 vs. 5.7 cm, IQR 4.9–7.4 cm, respectively, p < 0.01) compared with that of non-AA women.
This study demonstrates similar safety and efficacy of MRgFUS treatment for symptomatic uterine fibroids for all women, regardless of self-reported race. AA women present earlier for treatment with greater symptoms by age and have a larger number and smaller size fibroids. It has already been demonstrated that AA patients have larger uteri and a greater fibroid burden . Our subanalysis at a single institution indicates AA to have a higher screen failure rate due to multiple small fibroids compared with fewer and larger fibroids among non-AA, suggesting a different pattern of disease for AA. Despite the differences in presentation, once they passed screening and were treated with MRgFUS, the two groups do not differ in terms of their need for surgical intervention for failed MRgFUS treatment and in terms of their overall symptom improvement and fibroid shrinkage.
MRgFUS is an ambulatory, non-invasive technique for the treatment of uterine fibroids with a high safety profile  that enables patients to return to their routine daily activities rapidly, either on the day of the treatment or the day after . Previous studies showed that high-intensity focused ultrasound energy generated by MRgFUS to ablate uterine fibroids can clinically improve and shrink the fibroid without significant AEs . Other trials have reported significant long-term reductions in fibroid-associated symptoms [14, 27].
Considering the prevalence of fibroids in the AA population, the severity of their disease, and the high rates of hysterectomy and associated complications [28–33], it is important to understand that MRgFUS is a viable treatment option for this population from both a medical and a cost perspective. Three studies to date investigated the effect of uterine-preserving treatment for uterine fibroids [33–35], although none evaluated the potential differential effects between racial groups. We observed that at the time of enrollment, AA patients were younger, had more symptomatic fibroids (higher SSS QOL), and presented with different fibroid MR characteristics compared with non-AA patients (Table 1), which is consistent with previous studies [5, 34, 35].
The need for subsequent alternative treatments was similar for AA and non-AA, and the frequency was similar to those reported elsewhere during the 6 and 12 months post-treatment . Okada et al. reported a 4% re-intervention rate after 6 months and 9% re-intervention rates by 12 months in a population of 228 women treated with MRgFUS in four medical centers in Japan between 2003 and 2006 . Combining the results from the phase III and phase IV studies, both the short-term alternative treatment frequency (<12 months) and long-term alternative treatment rates were relatively high. In both groups, the intervention rates 1 year or less following the treatment was 11.6% compared with the 6.6% reported by Okada et al. . We reported alternative treatment rates of 33.3% and 46.1%, respectively, 2 and 3 years after the clinical studies. Intervention rates did not differ between the groups. The mean NPV achieved for both groups in our study was around 20%, which is similar to the NPV achieved in other early clinical trials [15, 36]. This is a very low NPV, compared with the higher rates now being achieved with more current technology [36, 37]. Previous studies have noted that higher NPV at the end of the treatment is associated with treatment success. It is important to note that our studies were carried out under restricted clinical trial guidelines leading to these low NPVs and these treatment limitations are not in place today.
The higher screen failure rate among AA found in our study should be the subject of future studies with higher numbers of patients. As our numbers were relatively small, it is possible that our findings were secondary to sample size. Today, as the enrollment criteria are less restrictive, it remains to be seen if the high screen failure rate persists.
We conclude that MRgFUS treatment is a safe and effective uterine-sparing treatment option for AA women. Further studies including longer follow-up of patients achieving higher NPV at the end of the treatment are needed to assess the long-term outcomes of the procedure among all women classified by race.
The authors thank Louise Greenberg, M.Ed., from our group for her help with patient recruitment, data collection, and follow-up; Alisa Suzuki, MD, for her help with the data collection; Nathan McDannold, PhD, Kullervo Hynynen, PhD, Xiangtao Yin, PhD, and Philip Jason White, PhD, from Brigham and Women’s Hospital for their technical assistance; the contributing members of the MRgFUS during one or more treatment protocols, Paul Curtis, MD, Virtua, Voorhees, NJ, USA, Phyllis Gee, MD, North Texas Uterine Fibroid Institute, Dallas, TX, USA, Gina Hesley, MD, Mayo Clinic, Rochester, MI, USA, George Holland, MD, Lahey Clinic, Burlington, MA, USA, Kevin Kim, MD, Johns Hopkins Hospital, Baltimore, MD, USA, Wanda Mott MD, Sightline, Houston, TX, USA, Dennis Sarti, MD, Radnet, Beverly Hills, CA, USA, Freed Steinberg MD, University MRI & Diagnostic Imaging Centers, Boca Raton, FL, USA; and the Focused Ultrasound Surgery foundation for their support with Dr. Machtinger’s fellowship. Insightec (Haifa, Israel) funded these clinical trials. Dr. Machtinger was supported by an award from the Focused Ultrasound Surgery Foundation for a part-time fellowship at the Brigham and Women’s Hospital.
- Stewart EA: Uterine fibroids. Lancet. 2001, 357: 293-8. 10.1016/S0140-6736(00)03622-9.View ArticlePubMedGoogle Scholar
- Walker CL, Stewart EA: Uterine fibroids: the elephant in the room. Science. 2005, 308: 1589-92. 10.1126/science.1112063.View ArticlePubMedGoogle Scholar
- Wu JM, Wechter ME, Geller EJ, Nguyen TV, Visco AG: Hysterectomy rates in the United States, 2003. Obstet Gynecol. 2007, 110: 1091-5. 10.1097/01.AOG.0000285997.38553.4b.View ArticlePubMedGoogle Scholar
- ACOG practice bulletin: Alternatives to hysterectomy in the management of leiomyomas. Obstet Gynecol. 2008, 112: 387-400. 10.1097/AOG.0b013e318183fbab.View ArticleGoogle Scholar
- Kjerulff KH, Langenberg P, Seidman JD, Stolley PD, Guzinski GM: Uterine leiomyomas. Racial differences in severity, symptoms and age at diagnosis. J Reprod Med. 1996, 41: 483-90.PubMedGoogle Scholar
- Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, Willett WC, Hunter DJ: Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol. 1997, 90: 967-73. 10.1016/S0029-7844(97)00534-6.View ArticlePubMedGoogle Scholar
- Huyck KL, Panhuysen CI, Cuenco KT, Zhang J, Goldhammer H, Jones ES, Somasundaram P, Lynch AM, Harlow BL, Lee H, Stewart EA, Morton CC: The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol. 2008, 198 (168): e161-9.Google Scholar
- Day BD, Dunson DB, Hill MC, Cousins D, Schectman JM: High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet. 2003, 188: 100-7. 10.1067/mob.2003.99.View ArticleGoogle Scholar
- Al-Hendy A, Salama SA: Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertil Steril. 2006, 86: 686-93. 10.1016/j.fertnstert.2006.01.052.View ArticlePubMedGoogle Scholar
- Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE: High aromatase expression in uterine leiomyoma tissues of African-American women. J Clin Endocrinol Metab. 2009, 94: 1752-6. 10.1210/jc.2008-2327.PubMed CentralView ArticlePubMedGoogle Scholar
- Marsh EE, Shaw ND, Klingman KM, Tiamfook-Morgan TO, Yialamas MA, Sluss PM, Hall JE: Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women. J Clin Endocrinol Metab. 2011, 96: 3199-206. 10.1210/jc.2011-1314.PubMed CentralView ArticlePubMedGoogle Scholar
- Peddada SD, Laughlin SK, Miner K, Guyon JP, Haneke K, Vahdat HL, Semelka RC, Kowalik A, Armao D, Davis B, Baird DD: Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci USA. 2008, 105 (50): 19887-92. 10.1073/pnas.0808188105.PubMed CentralView ArticlePubMedGoogle Scholar
- Taran FA, Brown HL, Stewart EA: Racial diversity in uterine leiomyoma clinical studies. Fertil Steril. 2010, 94: 1500-3. 10.1016/j.fertnstert.2009.08.037.View ArticlePubMedGoogle Scholar
- Stewart EA, Rabinovici J, Tempany CM, Inbar Y, Regan L, Gostout B, Hesley G, Kim HS, Hengst S, Gedroyc WM: Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril. 2006, 85 (1): 22-9. 10.1016/j.fertnstert.2005.04.072.View ArticlePubMedGoogle Scholar
- Stewart EA, Gostout B, Rabinovici J, Kim HS, Regan L, Tempany CM: Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol. 2007, 110: 279-87. 10.1097/01.AOG.0000275283.39475.f6.View ArticlePubMedGoogle Scholar
- Morita Y, Ito N, Hikida H, Takeuchi S, Nakamura K, Ohashi H: Non-invasive magnetic resonance imaging-guided focused ultrasound treatment for uterine fibroids - early experience. Eur J Obstet Gynecol Reprod Biol. 2007, 139: 199-203.View ArticlePubMedGoogle Scholar
- Hesley GK, Gorny KR, Henrichsen TL, Woodrum DA, Brown DL: A clinical review of focused ultrasound ablation with magnetic resonance guidance: an option for treating uterine fibroids. Ultrasound Q. 2008, 24: 131-9. 10.1097/RUQ.0b013e31817c5e0c.View ArticlePubMedGoogle Scholar
- Zowall H, Cairns JA, Brewer C, Lamping DL, Gedroyc WM, Regan L: Cost-effectiveness of magnetic resonance-guided focused ultrasound surgery for treatment of uterine fibroids. BJOG. 2008, 115: 653-62. 10.1111/j.1471-0528.2007.01657.x.PubMed CentralView ArticlePubMedGoogle Scholar
- Zaher S, Gedroyc WM, Regan L: Patient suitability for magnetic resonance guided focused ultrasound surgery of uterine fibroids. Eur J Obstet Gynecol Reprod Biol. 2009, 143: 98-102. 10.1016/j.ejogrb.2008.12.011.View ArticlePubMedGoogle Scholar
- Tempany CM, Stewart EA, McDannold N, Quade BJ, Jolesz FA, Hynynen K: MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology. 2003, 226: 897-905. 10.1148/radiol.2271020395.View ArticlePubMedGoogle Scholar
- Fennessy FM, Tempany CM, McDannold NJ, So MJ, Hesley G, Gostout B, Kim HS, Holland GA, Sarti DA, Hynynen K, Jolesz FA, Stewart EA: Uterine leiomyomas: MR imaging-guided focused ultrasound surgery–results of different treatment protocols. Radiology. 2007, 243: 885-93. 10.1148/radiol.2433060267.View ArticlePubMedGoogle Scholar
- Spies JB, Coyne K, Guaou Guaou N, Boyle D, Skyrnarz-Murphy K, Gonzalves SM: The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata. Obstet Gynecol. 2002, 99: 290-300. 10.1016/S0029-7844(01)01702-1.View ArticlePubMedGoogle Scholar
- Shen SH, Fennessy F, McDannold N, Jolesz F, Tempany C: Image-guided thermal therapy of uterine fibroids. Semin Ultrasound CT MR. 2009, 30: 91-104. 10.1053/j.sult.2008.12.002.PubMed CentralView ArticlePubMedGoogle Scholar
- Guidance for industry, collection of race and ethnicity data in clinical trials [Internet]. 2011, Rockville (MD, USA): U.S. Food and Drug Administration, Available from: http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm126396.pdf Accessed 2 October 2012
- Standard code of federal regulation definitions (21 CFR 312.32 IND safety reports) [Internet]. 2011, Rockville (MD, USA): U.S. Food and Drug Administration, Available from: http://www.fda.gov Accessed 5 October 2012
- Rabinovici J, Inbar Y, Revel A, Zalel Y, Gomori JM, Itzchak Y, Schiff E, Yagel S: Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance-guided focused ultrasound surgery. Ultrasound Obstet Gynecol. 2007, 30: 771-7. 10.1002/uog.4099.View ArticlePubMedGoogle Scholar
- Funaki K, Fukunishi H, Sawada K: Clinical outcomes of magnetic resonance guided focused ultrasound surgery for uterine myomas: 24-month follow-up. Ultrasound Obstet Gynecol. 2009, 34: 584-9. 10.1002/uog.7455.View ArticlePubMedGoogle Scholar
- Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM: High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003, 188: 100-7. 10.1067/mob.2003.99.View ArticlePubMedGoogle Scholar
- Jacoby VL, Fujimoto VY, Giudice LC, Kuppermann M, Washington AE: Racial and ethnic disparities in benign gynecologic conditions and associated surgeries. Am J Obstet Gynecol. 2010, 202: 514-21. 10.1016/j.ajog.2010.02.039.PubMed CentralView ArticlePubMedGoogle Scholar
- Wilcox LS, Koonin LM, Pokras R, Strauss LT, Xia Z, Peterson HB: Hysterectomy in the United States, 1988–1990. Obstet Gynecol. 1994, 83: 549-55. 10.1097/00006250-199404000-00011.View ArticlePubMedGoogle Scholar
- Kjerulff KH, Guzinski GM, Langenberg PW, Stolley PD, Moye NE, Kazandjian VA: Hysterectomy and race. Obstet Gynecol. 1993, 82: 757-64.PubMedGoogle Scholar
- Hakim RB, Benedict MB, Merrick NJ: Quality of care for women undergoing a hysterectomy: effects of insurance and race/ethnicity. Am J Public Health. 2004, 94: 1399-405. 10.2105/AJPH.94.8.1399.PubMed CentralView ArticlePubMedGoogle Scholar
- Roth TM, Gustilo-Ashby T, Barber MD, Myers ER: Effects of race and clinical factors on short-term outcomes of abdominal myomectomy. Obstet Gynecol. 2003, 101: 881-4. 10.1016/S0029-7844(03)00015-2.View ArticlePubMedGoogle Scholar
- Myers ER, Goodwin S, Landow W, Mauro M, Peterson E, Pron G, Spies JB: Worthington-Kirsch R; FIBROID Investigators. Prospective data collection of a new procedure by a specialty society: the FIBROID registry. Obstet Gynecol. 2005, 106: 44-51. 10.1097/01.AOG.0000165827.66541.dd.View ArticlePubMedGoogle Scholar
- Weiss G, Noorhasan D, Schott LL, Powell L, Randolph JF, Johnston JM: Racial differences in women who have a hysterectomy for benign conditions. Womens Health Issues. 2009, 19: 202-10. 10.1016/j.whi.2009.03.001.PubMed CentralView ArticlePubMedGoogle Scholar
- Okada A, Morita Y, Fukunishi H, Takeichi K, Murakami T: Non-invasive magnetic resonance-guided focused ultrasound treatment of uterine fibroids in a large Japanese population: impact of the learning curve on patient outcome. Ultrasound Obstet Gynecol. 2009, 34: 579-83. 10.1002/uog.7454.View ArticlePubMedGoogle Scholar
- Dobrotwir A, Pun E: Clinical 24 month experience of the first MRgFUS unit for treatment of uterine fibroids in Australia. J Med Imaging Radiat Oncol. 2012, 56 (4): 409-16. 10.1111/j.1754-9485.2012.02376.x.View ArticlePubMedGoogle Scholar
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