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3D MR neurography targeted peripheral nerve ablation with MR-guided high intensity focused ultrasound (MR-HIFU): initial results of a feasibility study in a swine model
© Staruch et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
MR-guided HIFU is an effective treatment for metastatic bone pain through periosteal nerve ablation, and is being investigated for treating back pain through facet joint denervation. For peripheral neuropathy, ultrasound-guided HIFU has been investigated preclinically as a means of achieving either an irreversible conduction block to treat severe spasticity, or a reversible partial conduction block to alleviate chronic pain. However, ultrasound offers limited visualization of deeply situated pelvic nerves  and lacks the ability to measure thermal dose, which predicts the extent of changes in peripheral nerve histology and function. Recently developed diffusion-prepared 3D MR neurography imaging techniques with fat suppression and nerve-selective T2-weighting  could improve targeting accuracy over ultrasound guidance. We present initial investigations into the use of MRI to guide HIFU ablation of peripheral nerves in a swine model. The objectives were 1) to evaluate the feasibility of identifying peripheral nerves using MR neurography on the clinical MR-HIFU system, 2) to monitor HIFU ablation of peripheral nerves using MR thermometry, and 3) to evaluate the ability to measure thermal lesions in peripheral nerves using contrast-enhanced T1-weighted images and thermal dose maps calculated from MR thermometry.
Experiments were approved by the local Institutional Animal Care and Use Committee. Volumetric MR-HIFU was used to induce seven thermal lesions in the sciatic nerves of three pigs. 3D MR neurography and T1-weighted images at 3T were used for target identification and treatment planning. A single 8 or 12 mm treatment cell was used to cover the full width of each targeted nerve. Ultrasound exposures were performed under MR thermometry guidance in five image planes across the HIFU beam, and one plane along the beam axis. Sonications were performed at 1.2 MHz with acoustic power ranging from 160 to 300 W over fixed durations of 20 or 36 seconds (energy 3.2 to 10.8 kJ). Ablation dimensions were measured and compared using thermal dose maps, contrast-enhanced T1-weighted images, and gross pathology.
Results and conclusions
Funded provided by the Cancer Prevention and Research Institute of Texas and the M.R. and Evelyn Hudson Foundation. Robert Staruch is a paid employee of Philips Research. The authors thank Dave Hitt of Philips Healthcare for technical support in customizing the MR neurography protocol for the swine model.
- Hurwitz , et al: Magnetic Resonance-Guided Focused Ultrasound for Patients With Painful Bone Metastases: Phase III Trial Results. JNCI. 2014, 106 (5):Google Scholar
- Weeks , et al: MRI-guided focused ultrasound (MRgFUS) to treat facet joint osteoarthritis low back pain-case series of an innovative new technique. Eur Radiol. 2012, 22: 2822-35. 10.1007/s00330-012-2628-6.View ArticlePubMedGoogle Scholar
- Foley , et al: Image-guided high-intensity focused ultrasound for conduction block of peripheral nerves. Ann Biomed Eng. 2007, 35: 109-19.View ArticlePubMedGoogle Scholar
- Foley , et al: Effects of high-intensity focused ultrasound on nerve conduction. Muscle Nerve. 2008, 37: 241-50. 10.1002/mus.20932.View ArticlePubMedGoogle Scholar
- Fritz , et al: Magnetic resonance neurography-guided nerve blocks for the diagnosis and treatment of chronic pelvic pain syndrome. Neuroimag Clin N Am. 2014, 24 (1): 211-34. 10.1016/j.nic.2013.03.028.View ArticleGoogle Scholar
- Vujaskovic , et al: Effects of intraoperative hyperthermia on peripheral nerves: neurological and electrophysiological studies. Int J Hyperthermia. 1994, 10 (1): 41-9. 10.3109/02656739409009330.View ArticlePubMedGoogle Scholar
- Yoneyama , et al: Rapid high resolution MR neurography with a diffusion-weighted pre-pulse. Magn Reson Med Sci. 2013, 12 (2): 111-9. 10.2463/mrms.2012-0063.View ArticlePubMedGoogle Scholar
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