Thermal dose and radiation dose comparison based on cell survival
© Lee et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
The biologic dose response curves of thermal dose and absorbed radiation dose have not been compared to each other even though they have both been extensively investigated separately and combined. Although heat and radiation produce cell kill by different biological mechanisms (Thermal dose denatures proteins and the radiation dose causes DNA damage) a comparison of dose response curves is possible using the endpoint of cell survival.
Survival curves for both thermal and radiation doses were extracted for three different types of cells from previously published data. Using models based on the beam shapes of the current clinical systems for the dose profile, the survival curves were generated and the survival profiles were compared for both modalities, Focused Ultrasound (FUS) and Gamma Knife (GK), for a thalamotomy. The thermal dose profile was calculated according to Dewey (1994), from temperature maps simulated with a 3D finite differences time domain code solving the bio-heat equation with a heat deposition term dependent on the pressure field. Radiosurgery dose distributions were exported from the Gamma Knife treatment planning software (Leksell GammaPlan versions 8.0 - 10.1, Elekta AB, Stockholm) with the smallest target as an input.
Results and conclusions
Focused Ultrasound Foundation
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.