Ultrashort echo-time MRI as a substitute to CT for skull aberration correction in transcranial focused ultrasound: in vitro comparison on human calvaria
© Aubry et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
Clinical transcranial MR-guided focused ultrasound (TcMRgFUS) brain treatment systems compensate for skull-induced beam aberrations by adjusting the phase and amplitude of individual ultrasound transducer elements. These corrections are currently calculated based on a pre-acquired CT scan of the patient’s head. The purpose of the work presented here is to demonstrate the feasibility of using ultrashort echo-time (UTE) MRI instead of CT to calculate and apply aberration corrections on a clinical TcMRgFUS system.
Phantom experiments were performed in three ex vivo human skulls filled with tissue mimicking hydrogel. Each skull phantom was imaged with both CT and UTE MRI. The MR images were then segmented into “skull” and “not-skull” pixels using a computationally efficient, threshold-based algorithm, and the resulting three-dimensional binary skull map was converted into a series of two-dimensional virtual CT images. Each skull was mounted in the head transducer of a clinical TcMRgFUS system (ExAblate Neuro, Insightec, Israel), and transcranial sonications were performed using a power setting of approximately 750 Acoustic Watts at several different target locations within the electronic steering range of the transducer. Each target location was sonicated three times: once using aberration corrections calculated from the actual CT scan, once using corrections calculated from the MRI-derived virtual CT scan, and once without applying any aberration correction. MR thermometry was performed in conjunction with each 10-second sonication, and the highest single-pixel temperature rise and surrounding-pixel mean were recorded for each sonication.
Results and conclusions
Jean-Francois Aubry is a consultant for the Focused Ultrasound Foundation.
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