Volume 3 Supplement 1
Quantifying perfusion-related energy losses during magnetic resonance-guided focused ultrasound
© Dillon et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
The focused ultrasound power required for successful ablation of uterine fibroid tissue varies substantially between patients and within single treatments.[1, 2] Fibroids with high signal intensity in pretreatment T2-weighted MR images have been shown to require increased power to achieve adequate temperature elevation for ablation;[2, 4] thus, T2-weighted signal intensity has been suggested as a predictor of MRgFUS treatment response.[2, 3] Physiologically, the high intensity of T2-weighted MR images of uterine fibroids may represent vascularization, fluid-rich tissues, or degeneration.[4, 6] By quantifying perfusion-related energy losses (Qb) during MRgFUS treatments, this study is the first step in linking perfusion-related energy losses with MR perfusion imaging. This knowledge could be used to improve biothermal modeling of MRgFUS fibroid treatments and as a potential independent predictor of treatment response and outcome.
Results and conclusions
This work was funded by Siemens Healthcare AG, the FUS Foundation, the Ben and Iris Margolis Foundation, and by NIH grants R01 CA87785 and R01 EB013433.
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