Fig. 6

Ultrasound applied to MS-model mice successfully activates brain. a Mean and standard error of EEG signals recorded from a representative mouse within each MS and ultrasound protocol. Horizontal lines denote either the mean value of the EEG signal during ultrasound application, hence observed brain activation (the first 19 ms) or the mean value of the EEG signal during the time without ultrasound (the ‘background’, during the subsequent 31 ms). b Calculated for every 50-ms pair in the time series for each mouse, and aggregated across all mice for each protocol, this figure’s boxplots show the difference between mean brain activity induced by ultrasound and mean background brain activity, normalized by the absolute value of the mean background brain activity. (0.625 MHz, n = 4; 1.09 MHz, n = 4; 2.0 MHz, n = 4)