Table 1 List of clinical trials investigating neurological applications of MRgFUS by disorder

ET

Phase II

NCT02289560 – multi-centered, single arm study to look at efficacy for ET

NCT01827904 - prospective, randomized, double blind, crossover, multi-centered, two arm study to test efficacy and further demonstrate safety

PD

Phase I

NCT02347254, NCT01772693, NCT02263885, NCT02246374, NCT02252380 - phase I trial to study unilateral Vim nucleus/subthalamic nucleus/globus pallidus sonication for PD

Brain tumor – ablation

Phase I

NCT00147056, NCT02343991, NCT01473485 – phase I trial for tumor ablation, ongoing

NCT01698437 – phase I trial for tumor ablation, completed, University Children’s Hospital in Zurich

Brain tumor – BBB disruption

Phase I

NCT02343991 – phase I trial to study BBB opening for delivery of doxorubicin

Depression/anxiety

Phase I

NCT02348411 – phase I trial to study safety and initial effectiveness of MRgFUS bilateral anterior capsulotomy in medication-refractory MDD

NCT02685488 – phase I trial of right frontotemporal area sonication for mild to moderate depression

OCD

Phase I

NCT01986296 - phase I trial of anterior cingulate cortex, anterior limb of internal capsule, ventral striatum or subgenual cingulate cortex sonication

NCT03156335 - phase I trial to evaluate the safety and efficacy of MRgFUS for patients with treatment-refractory OCD

Pain syndromes

Phase I

NCT01699477 - phase I trial of thalamic sonication for neuropathic pain, pediatric, University Children’s Hospital in Zurich

Central lateral thalamic nucleus sonication (Neurosurgery Focus 2012)

NCT03111277 - phase I trial for MRgFUS thalamotomy of central lateral thalamic nucleus

Epilepsy – ablation

Phase I

NCT02804230 – phase I trial, ablation of subcortical focal epileptic targets

Epilepsy - neuromodulation

Phase I

NCT02151175 – phase I trial, stimulation or suppression of neuronal activity in temporal lobe

AD

Phase I

NCT02986932 – phase I trial of ultrasound mediated BBB opening for AD

Thrombolysis/ICH

Preclinical

Swine and human cadaveric models demonstrated feasibility of ICH liquefaction. Rabbit carotid occlusion model demonstrated feasibility of this model for vascular recanalization

CSF diversion

Preclinical

Proof-of principle study of MRgFUS third ventriculostomy

Neuromodulation

Phase I

Vagus nerve modulation can stimulate or dampen neuronal activity