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Table 4 HIFU Technical parameters

From: A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound

Author, date HIFU device HIFU Transducer features Intensity and frequency Acoustic output power Continuous or pulsed wave Number of sessions
Xiong, 2001 [53] FEB-BY01 HIFU System N/A N/A input power: 1–2 kW pulsed 9.5 average, max 15
Xu, 2003 [54] FEB-BY01 HIFU System N/A N/A input power: 1–2 kW pulsed 6.5 average, max 12
Yuan, 2003 [55] FEB-BY01 HIFU System effective treatment depth 3.5–14.0 cm; practice focused sphere 0.3 × 0.3 × 0.8 cm; effective focused sphere of 0.6 × 0.6 × 0.6 cm N/A 1–2 kW pulsed 40 patients received in total more than 280 HIFU treatments (2–4 times for smaller tumour focus)
Gu, 2004 [21] FEB-BY01 HIFU System depth of effective therapy 2–15 cm; actual focus measurement 0.3 × 0.3 × 0.8 cm; effective focus of 0.6 × 0.6 × 1 cm N/A 1–2 kW average: 1.5 kW pulsed 6 average (range 3–14)
Li, 2004 [22] FEB-BY02 HIFU System effective therapy depth of 2–15 cm; practice focused sphere of 0.3 × 0.3 × 0.8 cm; effective focused sphere 0.6 × 0.6 × 1 cm N/A 1–2 kW pulsed 8.4 average (range 5–12). Patients with abdominal and back pain got abdominal ganglion treatment 1–2 times per patient
Wu, 2005 [32] Model-JC HIFU System 12 cm diameter; focal length 13.5 cm; focal region: 9.8 mm along beam axis, 1.3 mm in transverse direction 0.8 MHz; Acoustic focal peak intensity: 10 to 15 kW/cm2 N/A continuous 1.5 average (2 patients had 2 sessions, 6 patients had 1 session)
Xie, 2008 [56] HIFUNIT-9000 HIFU System effective therapy depth: 17 cm; focused sphere: 0.3 × 0.3 × 0.8 cm 1 MHz maximum output power: 600 W in the study: 200–300 W continuous 4.25 average (range 2–8)
Xiong, 2009 [44] FEB-BY HIFU System overall aperture 37 cm; focal length 26 cm; -6 dB focal dimensions: 0.8 cm in length, 0.3 cm in diameter 1.04 MHz 250–430 W pulsed 4–10 sessions
Zhao, 2010 [45] HIFUNIT-9000 HIFU System effective therapy depth 2–15 cm; practice focused sphere 0.3 × 0.3 × 1 cm N/A Input power: 3 kW/cm2 continuous Gemcitabine on days 1, 8 and 15, and multiple HIFU sessions on days 1, 3 and 5. The combined treatment repeated every 28 days
Orsi, 2010 [57] Model-JC HIFU System 20 cm diameter; focal length 15 cm 0.8 MHz 200–400 W continuous single session
Wang, 2011 [33] Model-JC HIFU System 20 cm diameter, focal length 13.5 cm; focal region: 8 mm along beam axis, 1.5 mm in transverse direction 0.85 MHz mean power range: 117–388 W median: 247 W continuous single session
Sung, 2011 [35] Model-JC HIFU System 20 cm diameter; system operated by using one of several therapeutic transducers with focusing lengths that varied from 9 to 16 cm (13.7 cm focusing length most used in the study) 0.8 MHz (either 0.8 or 1.6 MHz for each focal length, but 0.8 most commonly used) 140–240 W (200 W most commonly used) continuous single session
Orgera, 2011 [58] Model-JC HIFU System diameter 20 cm; focal length 15 cm 0.8 MHz 60–400 W continuous single session
Li, 2012 [59] FEB-BY02 HIFU System aperture of 37 cm; focal distance 25.5 cm; focus has a 6 dB beam width of 1.6 mm and an axial length of 1 cm; effective therapy depth 2-15 cm 1 MHz 400–1000 W mean: 586 +/- 78.4 W pulsed 1.2 average (19 patients had 1 session, 6 patients had 2 sessions)
Gao, 2013 [60] Model-JC HIFU System diameter 20 cm; focal length 13.5 cm 0.85 MHz N/A continuous 33 patients had 1 session, 4 patients had 2 sessions, and others more than 2 sessions
Anzidei, 2014 [24] ExAblate 2100; InSightec diameter 12 cm; radius of curvature 16 cm; focal distance 6–20 cm 0.95–1.35 MHz N/A   single session
Sofuni, 2014 [61] FEB-BY02 HIFU System aperture of the ultrasound array 37 cm; radius of curvature 25.5 cm 1.1 MHz input electric power: 0.5–2 kW pulsed 2.7+/-0.1 SD
Marinova, 2016a [23] Model-JC HIFU System 20 cm diameter; focal length 15 cm 0.8 MHz range: 80–400 W average: 344 +/-72 W (200–400) continuous single session
Li YJ, 2016 [34] N/A N/A 0.8 MHz 300 W N/A N/A
Li X, 2016 [49] Model-JC HIFU System N/A N/A N/A N/A single session
Strunk, 2016 [62] Model-JC HIFU System diameter 20 cm; focal length 15 cm 0.8 MHz 200–400 W continuous single session
Lv, 2016 [48] JC200 HIFU System focus 14.7 cm 0.97 MHz average: 350 W continuous single treatment expected, but additional treatments can be added when necessary
Marinova, 2016b [36] Model-JC HIFU System diameter 20 cm; focal length 15 cm 0.8 MHz N/A continuous single session