Table 2 Summary of the results of the included studies on HIFU therapy in pancreatic cancer
From: A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound
Author, Date | Pain Evaluation | Number of patients with pain at baseline | Number of patients with pain relief | % Patients with pain reduction | Pain Scale 0–10 | HIFU related adverse effects (#pt) | ||
|---|---|---|---|---|---|---|---|---|
Before HIFU | after HIFU | Minor | Major | |||||
Xiong, 2001 [53] | Pain Scale | 17 | 15 | 0.88 | 7 +/- 2.1 | 3 +/- 1.5 | None | Jaundice (1) |
Xu, 2003 [54] | Pain Scale | 30 | 24 | 0.80 | 5.6 +/- 3.2 | 2.0 +/- 1.9 | Dilation of pancreatic duct with steatorrhea (3) | None |
Yuan, 2003 [55] | Pain Category | 40 | 32 | 0.80 | N/A | N/A | None | None |
Gu, 2004 [21] | N/A | 38 | 36 | 0.95 | N/A | N/A | N/A | N/A |
Li, 2004 [22] | Pain Scale | 10 | 9 | 0.90 | N/A | N/A | Skin burn II (1) | None |
Wu, 2005 [32] | Drug Needs | 8 | 8 | 1.00 | N/A | N/A | None | None |
Xie, 2008 [56] | N/A | 16 | 14 | 0.88 | N/A | N/A | Skin burn (1) | Jaundice aggravation(1) |
Xiong, 2009 [44] | Pain Scale | 67 | 54 | 0.81 | N/A | N/A | Skin burn II (3), Subcutaneous sclerosis (6), Pancreatic pseudocyst (1) | None |
Zhao, 2010 [45] | VAS + Use of opioids | 28 | 22 | 0.79 | N/A | N/A | None | None |
Orsi, 2010 [57] | N/A | 6 | 5 | 0.83 | N/A | N/A | None | Portal Vein Thrombosis (1) |
Wang, 2011 [33] | Pain Scale | 40 | 35 | 0.88 | N/A | N/A | None | None |
Sung, 2011 [35] | VAS | 25 | 24 | 0.96 | 4.9 +/- 1.1 range 4–9 | 2.1 +/- 1.1 range 0–5 | Mild abdominal pain (16), Transient pancreatitis (7), Transient fever (3), Severe abdominal pain with vomiting (2) | Pancreaticoduodenal fistula (2),Skin burn II (1), Skin burn III (1) |
Orgera, 2011 [58] | Use of opioids | 3 | 3 | 1.00 | N/A | N/A | None | None |
Li, 2012 [59] | Pain scale | 25 | 23 | 0.92 | 4.6 +/- 2.1 | 2.2 +/- 0.9 | Skin burn I (3) | None |
Gao, 2013 [60] | Pain Scale | 39 | 31 | 0.79 | N/A | N/A | None | None |
Anzidei, 2014 [24] | Pain Scale | 6 | 6 | 1.00 | 7 +/- 1 | 3 +/- 1 | None | None |
Sofuni, 2014 [61] | Pain Scale | 21 | 16 | 0.76 | N/A | N/A | Mild pancreatitis (1) Pseudocyst formation (2) | None |
Marinova, 2016a [23] | Pain Scale | 13 | 10 | 0.77 | N/A | N/A | Mild to severe abdominal pain (7), Skin burn II (1), Induration subcutaneous fat tissue (1), Local edema (6), Increase in pancreatic lipase (3) | Severe abdominal pain requiring hospitalisation (1) |
Li YJ, 2016 [34] | Pain Scale | 16 | 15 | 0.94 | 5.1 +/- 2.2 | 3.3 | None | None |
Li X, 2016 [49] | Pain Scale | 61 | 35 | 0.57 | 6 | N/A | Slight skin burns | None |
Strunk, 2016 [62] | Pain Scale + Use of opioids | 15 | 12 | 0.80 | N/A | N/A | Transient subcutaneous edema (9), Skin burn II (1), Subcutaneous sclerosis (1), Lipase increase (3) | None |
Lv, 2016 [48] | Memorial Pain Assessment Card | 23 | 15 | 0.65 | N/A | N/A | None | None |
Marinova, 2016b [36] | Pain Scale | 20 | 15 | 0.75 | 3.75 +/- 2.07 | 1.60 +/- 1.35 | Mild severe abdominal pain (13), Cutaneous/subcutaneous edema (11), Subcutaneous tissue induration (1), Skin burn IIa (1), Increase in lipase (3) | None |