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Table 2 Summary of the results of the included studies on HIFU therapy in pancreatic cancer

From: A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound

Author, Date Pain Evaluation Number of patients with pain at baseline Number of patients with pain relief % Patients with pain reduction Pain Scale 0–10 HIFU related adverse effects (#pt)
Before HIFU after HIFU Minor Major
Xiong, 2001 [53] Pain Scale 17 15 0.88 7 +/- 2.1 3 +/- 1.5 None Jaundice (1)
Xu, 2003 [54] Pain Scale 30 24 0.80 5.6 +/- 3.2 2.0 +/- 1.9 Dilation of pancreatic duct with steatorrhea (3) None
Yuan, 2003 [55] Pain Category 40 32 0.80 N/A N/A None None
Gu, 2004 [21] N/A 38 36 0.95 N/A N/A N/A N/A
Li, 2004 [22] Pain Scale 10 9 0.90 N/A N/A Skin burn II (1) None
Wu, 2005 [32] Drug Needs 8 8 1.00 N/A N/A None None
Xie, 2008 [56] N/A 16 14 0.88 N/A N/A Skin burn (1) Jaundice aggravation(1)
Xiong, 2009 [44] Pain Scale 67 54 0.81 N/A N/A Skin burn II (3), Subcutaneous sclerosis (6), Pancreatic pseudocyst (1) None
Zhao, 2010 [45] VAS + Use of opioids 28 22 0.79 N/A N/A None None
Orsi, 2010 [57] N/A 6 5 0.83 N/A N/A None Portal Vein Thrombosis (1)
Wang, 2011 [33] Pain Scale 40 35 0.88 N/A N/A None None
Sung, 2011 [35] VAS 25 24 0.96 4.9 +/- 1.1 range 4–9 2.1 +/- 1.1 range 0–5 Mild abdominal pain (16), Transient pancreatitis (7), Transient fever (3), Severe abdominal pain with vomiting (2) Pancreaticoduodenal fistula (2),Skin burn II (1), Skin burn III (1)
Orgera, 2011 [58] Use of opioids 3 3 1.00 N/A N/A None None
Li, 2012 [59] Pain scale 25 23 0.92 4.6 +/- 2.1 2.2 +/- 0.9 Skin burn I (3) None
Gao, 2013 [60] Pain Scale 39 31 0.79 N/A N/A None None
Anzidei, 2014 [24] Pain Scale 6 6 1.00 7 +/- 1 3 +/- 1 None None
Sofuni, 2014 [61] Pain Scale 21 16 0.76 N/A N/A Mild pancreatitis (1) Pseudocyst formation (2) None
Marinova, 2016a [23] Pain Scale 13 10 0.77 N/A N/A Mild to severe abdominal pain (7), Skin burn II (1), Induration subcutaneous fat tissue (1), Local edema (6), Increase in pancreatic lipase (3) Severe abdominal pain requiring hospitalisation (1)
Li YJ, 2016 [34] Pain Scale 16 15 0.94 5.1 +/- 2.2 3.3 None None
Li X, 2016 [49] Pain Scale 61 35 0.57 6 N/A Slight skin burns None
Strunk, 2016 [62] Pain Scale + Use of opioids 15 12 0.80 N/A N/A Transient subcutaneous edema (9), Skin burn II (1), Subcutaneous sclerosis (1), Lipase increase (3) None
Lv, 2016 [48] Memorial Pain Assessment Card 23 15 0.65 N/A N/A None None
Marinova, 2016b [36] Pain Scale 20 15 0.75 3.75 +/- 2.07 1.60 +/- 1.35 Mild severe abdominal pain (13), Cutaneous/subcutaneous edema (11), Subcutaneous tissue induration (1), Skin burn IIa (1), Increase in lipase (3) None