Fig. 74 (abstract O56).

Results Highlights. a a Short axis ultrasound (US) imaging of noninvasive HIFU pacing in a rat. The HIFU focus is marked by the curser which is placed on the most dorsal part of the rat’s left ventricle. A sequence of premature ventricular contractions (PVCs), were successively paced by US guided multi harmony HIFU insonation. The PVC sequence is marked on the ECG trace. b A rat heart following HIFU pacing showing no sign of gross damage and an example of Eosin (H&E) staining showing no sign of inflammation 24 hours post pacing. c-e Numerical simulation results of multi harmony HIFU pacing in a small animal model cardiomyocyte demonstrating Premature Action Potentials (PAPs) induction throughout the entire diastole and showing PAP peak voltage was assumed within the same temporal delay from insonation onset as was demonstrated by extracorporeal HIFU pacing in rats. Contractions (PVCs), were successively paced by US guided multi harmony HIFU insonation. The PVC sequence is marked on the ECG trace. b A rat heart following HIFU pacing showing no sign of gross damage and an example of Eosin (H&E) staining showing no sign of inflammation 24 hours post pacing. c-e Numerical simulation results of multi harmony HIFU pacing in a small animal model cardiomyocyte demonstrating Premature Action Potentials (PAPs) induction throughout the entire diastole and showing PAP peak voltage was assumed within the same temporal delay from insonation onset as was demonstrated by extracorporeal HIFU pacing in rats