Table 2 Potential large animal application with DUS-targeted gene delivery
| Disease entity | DUS frequency/trigging | Specific gene | Specific application |
|---|---|---|---|
| Diabetes | 1:4 | DNA-planned | Beta cell regeneration |
| Limb ischemia | 1:4 | DNA-planned VGE | Angiogenesis |
| Tumor | DNA | Tumor suppression | |
| Tumor | 1:10 | ShRNA | Anti-angiogenesis |