Fig. 4

Example of MRI anatomical images with registered thermal maps. All temperature maps were thresholded at 15 °C before overlaying them onto the MR image. Images are representative MR images of rat livers acquired in a vertical plane passing through the ultrasound focus. a is a representative of the thermal profile observed before any agents were injected. b, c, and d are representatives of the thermal profiles 5, 15, and 95 min after the injection of nanodroplets (ND). e, f, and g are representatives of the thermal profiles 5, 15, and 95 min after the injection of microbubbles (MB). The white scale bars indicate 1 cm, and the black crosshairs indicate the intended target location