Fig. 2

Temperature rise as a function of depth into the liver, calculated from the temperature maps. The heating profiles are plotted versus depth, with the solid dark line indicating the mean profile averaged over all sonications (n = 3, 4, or 5; see Table 1) performed at a given time point using a given agent and the pale area indicating a single standard deviation about the mean. Each plot shows the mean heating profile reached after 15 s of HIFU, applied a 5 min, b 15 min, or c 95 min following injection of microbubbles (MB), nanodroplets (ND), or the sham case (Control) where no agents were injected (this curve is the same in all three panels)