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Table 1 Tissue properties[2], voxel size = 0.5x0.5x0.685 mm, calculation time = 80 min, thermal properties[3].

From: Acoustic and thermal simulations of tcMRgFUS in patient specific models: validation with experiments

Simulation-Type

Attenuation (Np/cm)

Speed of Sound (m/s)

Density (kg/m3)

A. Skull Efficiency

avoxel = amin + (amax – amin)(1 – Ø)

amin = 0.08, amax = 3.2

cvoxel = cmin + (cmax – cmin)(1 – Ø)

cmin = 1500, cmax = 2100

dvoxel = Ø x dwater + (1 – Ø)dbone

dwater = 1000, dbone = 2100

B. Attenuation-only

avoxel = amin + (amax – amin)(1 – Ø)

Homogeneous = 1550

Homogeneous = 1000

C. Phase Aberration-only

Homogeneous = 0.08

cvoxel = cmin + (cmax – cmin)(1 – Ø)

d’voxel = 1000/cvoxel

D. Reflection-only

Homogeneous = 0.08

Homogeneous = 1550

d’voxel = dvoxel x cvoxel

E. Attenuation and Reflection

avoxel = amin + (amax – amin)(1 – Ø)

Homogeneous = 1550

d’voxel = dvoxel x cvoxel