- Oral presentation
- Open Access
MR guided focused ultrasound treatment of soft tissue tumors of the extremities — preliminary experience
© Ghanouni et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
Soft tissue tumors are a heterogeneous group of tumors arising from connective tissues. These tumors may be benign, benign but locally aggressive, or malignant. Surgery either alone or in combination with adjuvant therapies such as radiation or chemotherapy can potentially cure a patient with a soft tissue tumor. The morbidity and complications associated with treatment can have significant and lasting adverse effects on limb function and quality of life. In some situations, patients develop local recurrence of disease and require further surgery, which can result in further treatment-associated morbidity. We have adapted MR guided focused ultrasound (MRgFUS) techniques to the treatment of benign and malignant soft tissue tumors of the extremities with the goal of safely and effectively performing MRgFUS ablation on human subjects. This presentation describes the use of MRgFUS for the treatment of desmoid fibromatosis, arteriovenous malformations, and malignant sarcomas.
Patients were treated using an MR imaging-guided focused ultrasound system (ExAblate 2100, InSightec, Ltd, Tirat Carmel, Israel). Treatments were performed under general or regional anesthesia. Patients were positioned such that the targeted tumor was overlying the transducer, using a gel mold for positioning and for coupling to the transducer.
MR images were obtained to define the tumor volume and surrounding critical structures in preparation for therapy. The treatment planning software was utilized to define the skin surface as well as the contour of the tumor to be treated. Fiducial markers were placed on the images to monitor for patient motion. Sonication planning was managed by the ExAblate software, and modified as needed by the treating physician. MR generated thermal dose maps were used to confirm heating in the tumor, and to monitor heat accumulation on the skin.
Post-contrast imaging was used to assess the extent of ablation within the targeted tumor. Patients were transferred to a recovery area and monitored prior to discharge home.
Results and conclusions
buttock and thigh
For malignant tumors, there may be a role for MRgFUS in the management of local recurrences. For benign but locally aggressive tumors such as desmoid fibromatosis, where current standard therapies are often ineffective and are associated with significant morbidity, minimally invasive treatment with MRgFUS may be an appropriate first-line therapy.
Challenges to the utilization of MRgFUS for these applications include patient positioning on the MRgFUS table, coupling the targeted area to the transducer, reliable intra-operative treatment monitoring, and speed of treatment for large tumors. More technical development and evidence is needed before MRgFUS can be used routinely for the treatment of soft tissue tumors.
NIH P01 CA159992
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