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Journal of Therapeutic Ultrasound

Open Access

Parkinson’s tremor

  • Jeff Elias1 and
  • Robert Dallapiazza1
Journal of Therapeutic Ultrasound20153(Suppl 1):O2

Published: 30 June 2015


Public HealthClinical TrialPilot StudyPrimary OutcomeOutcome Variable


Tremor associated with Parkinson’s disease can be medication resistant and disabling. A clinical trial of stereotactic focused ultrasound thalamotomy is underway.


This pilot study is being conducted in two centers with a randomized, controlled study design using blinded and validated rater assessments and a sham procedure. The primary outcome variable is hand tremor and the Unified Parkinson’s disease rating scale in the medicated state at three months. Comprehensive cognitive assessments before and after the procedure are being conducted for additional safety. A total of thirty patients will be enrolled.

Authors’ Affiliations

University of Virginia, Charlottesville, United States


© Elias and Dallapiazza; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.