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Essential tremor


A randomized controlled trial of unilateral stereotactic MRI-guided focused ultrasound thalamotomy is underway.


Seventy-two patients with severe, medication-refractory essential tremor have been enrolled across seven international centers. Standard assessments of tremor severity and disability will be obtained before and after the procedure. Patients are randomized in a one-to-three fashion to receive either sham procedure or MR-guided focused ultrasound thalamotomy. The Tremor Research Group, neurologist specialists in the management of essential tremor, will rate the clinical outcomes from videotaped assessments.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Elias, J. Essential tremor. J Ther Ultrasound 3 (Suppl 1), O1 (2015).

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