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Table 3 Changes in pain score, analgesic intake, and response

From: Feasibility of volumetric MRI-guided high intensity focused ultrasound (MR-HIFU) for painful bone metastases

Treatment Pain scores (NRS) Analgesic intakec Responsed
  Baseline Day 3 1 Month   
1a 7 4 4 Stable PR
1ba 7 7 7 Stable NR
2 8 8 7 Stable NR
3 8 9 2 Stable PR
4 6 6 7 Stable NR
5a 8 8 4 Reduction PR
6 9 4 0 Increase PR
7 4 2 5 Stable NR
5ba 10 8 5 Reduction PR
8 9 7 0 Stable CR
9 6 6 1 Reduction PR
10b 9 4 - - -
11b 7 7 - - -
  1. Abbreviations: NRS numeric rating scale.
  2. aSecond treatment in the same patient was not included in the response analysis.
  3. bNo follow-up data available at 30 days after treatment, only included in response analysis at 3 days.
  4. cAt 1 month after treatment compared to baseline; reduction is defined as ≥25% decrease in daily oral morphine equivalent (OMED), increase is defined as ≥25% increase in OMED, and stable is defined as neither increase nor decrease[33, 34].
  5. dResponse at 1 month as defined by the updated International Bone Metastases Consensus Working Party[33, 34]. Partial response (PR): pain reduction of ≥2 or more at the treated site on a 0 to 10 scale without analgesic increase or analgesic reduction without increase in pain. Complete response (CR): pain score of 0 at the treated site with no concomitant increase in analgesics. No response (NR): no partial or complete response.