Treatment | Pain scores (NRS) | Analgesic intakec | Responsed |
|---|
| Â | Baseline | Day 3 | 1 Month | Â | Â |
|---|
1a | 7 | 4 | 4 | Stable | PR |
1ba | 7 | 7 | 7 | Stable | NR |
2 | 8 | 8 | 7 | Stable | NR |
3 | 8 | 9 | 2 | Stable | PR |
4 | 6 | 6 | 7 | Stable | NR |
5a | 8 | 8 | 4 | Reduction | PR |
6 | 9 | 4 | 0 | Increase | PR |
7 | 4 | 2 | 5 | Stable | NR |
5ba | 10 | 8 | 5 | Reduction | PR |
8 | 9 | 7 | 0 | Stable | CR |
9 | 6 | 6 | 1 | Reduction | PR |
10b | 9 | 4 | - | - |
-
|
11b | 7 | 7 | - | - |
-
|
- Abbreviations: NRS numeric rating scale.
- aSecond treatment in the same patient was not included in the response analysis.
- bNo follow-up data available at 30Â days after treatment, only included in response analysis at 3Â days.
- cAt 1 month after treatment compared to baseline; reduction is defined as ≥25% decrease in daily oral morphine equivalent (OMED), increase is defined as ≥25% increase in OMED, and stable is defined as neither increase nor decrease[33, 34].
- dResponse at 1 month as defined by the updated International Bone Metastases Consensus Working Party[33, 34]. Partial response (PR): pain reduction of ≥2 or more at the treated site on a 0 to 10 scale without analgesic increase or analgesic reduction without increase in pain. Complete response (CR): pain score of 0 at the treated site with no concomitant increase in analgesics. No response (NR): no partial or complete response.
