Feasibility of volumetric MRI-guided high intensity focused ultrasound (MR-HIFU) for painful bone metastases

Table 1 Patient and lesion characteristics

Patient	Sex	Age (years)	ECOG ps	Primary tumor	Location	Lesion type	Cortex^c	Lesion dimensions (mm)^d
1 lesion a^a	M	58	1	Kidney	Femur	Lytic	Complete destruction	69 × 63 × 131
1 lesion b^a	M	58	1	Kidney	Femur	Lytic	Complete destruction	84 × 52 × 100
2	F	55	1	Kidney	Sacrum	Lytic	Complete destruction	64 × 27 × 64
3	F	56	1	Colorectal	Pubic bone	Mixed	Partially intact	59 × 22 × 23
4	M	60	1	Colorectal	Pubic bone	Lytic	Complete destruction	62 × 36 × 45
5^b	F	64	0	Breast	Sacrum	Mixed	Intact	107 × 56 × 56
6	F	53	2	Breast	Humerus	Blastic	Intact	36 × 28 × 23
7	M	86	1	Sarcoma	Rib	Mixed	Partially intact	56 × 39 × 46
8	M	55	1	Prostate	Pubic bone	Lytic	Partially intact	64 × 44 × 45
9	M	71	1	Lung	Pubic bone	Lytic	Complete destruction	69 × 48 × 75
10	M	65	2	Colorectal	Rib	Mixed	Partially intact	122 × 29 × 29
11	M	64	2	Mesothelioma	Rib	Lytic	Partially intact	74 × 9 × 6

Abbreviations: ECOG ps Eastern Cooperative Oncology Group performance score.
^aPatient 1 was treated on two locations: 1a midshaft left femur and 1b distal left femur.
^bPatient 5 was retreated on the same location 4 months after the first treatment because of recurrent pain.
^cAppearance on x-ray or CT-imaging (if available) before treatment: intact = no or minimal architectural distortion of the cortical bone by the tumor; partially intact = both destructed and intact cortical bone in the targeted area; complete destruction = cortical bone completely displaced by tumor.
^dLong axis (transversal) × short axis (transversal) × craniocaudal dimension (coronal) as measured on pretreatment CE-MRI.

ISSN: 2050-5736