Example of temperature increase during sonication. The graph displays the maximal temperature reached in the target area during a therapeutic sonication in a bone metastasis in the pubic bone with a partially intact cortex (near-field approach). The green area indicates the duration of sonication. The values displayed are based on the voxel with the highest temperature. The sagittal magnitude images with temperature color map overlays show the temperature increase at the bone-soft-tissue interface (encircled in white); orange and red colors indicate a temperature over 56°C.