Figure 5From: Trans-cranial opening of the blood-brain barrier in targeted regions using astereotaxic brain atlas and focused ultrasound energyValidation with the animal model. Evans blue dye leakage served asprimary validation. A.1/A.2 shows BBB opening on therat/mouse separately. A photo of the entire brain is referred at the corner;bar is 5 mm. T1‒weighted spin‒echomulti‒slice MR images (TR/TE, 151/10 ms) were acquired with ratas secondary validation. B.1 and B.2 show images intransverse and coronal directions, respectively. Yellow rectanglehighlighted the brain, and contrast enhancement (white arrow)indicates localized BBB opening.Back to article page