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Table 2 Treatment characteristics

From: First experience with MR-guided focused ultrasound in the treatment of Parkinson's disease

 

Patient no.

Sonication target and side

Final temperature (°C)

Global symptom relief 3 months (%)

Pre-FUS UPDRS I/II/III/IV (max. 16/52/56/23, total 147)

3 months post-FUS UPDRS I/II/III/IV (max. 16/52/56/23, total 147)

Pre-FUS MMST (max. 30)

3 months post-FUS MMST (max. 30)

Pre-FUS HADS (max. 42)

3 months post-FUS HADS (max. 42)

Group 1

1

PTT right

52

0

0/2/3/6

2/11/5/7

29

30

17

20

Total 11

Total 25

2

PTT right

52

30

0/14/17/3

0/10/17/2

30

30

9

4

Total 34

Total 29

3

PTT right

57

40

0/18/29/4

1/20/24/2

29

29

12

18

Total 51

Total 47

4

PTT right

59

20

0/18/26/5

0/12/20/1

27

27

13

9

Total 49

Total 33

Group 2

5

PTT right

59

50

0/5/18/5

0/1/7/0

30

30

5

9

Total 28

Total 8

6

PTT left

57

55

1/10/15/5

0/6/6/0

29

30

20

19

Total 31

Total 12

7

PTT left

57

80

4/21/20/6

1/12/2/4

30

30

13

14

Total 51

Total 19

8

PTT right

58

5

0/10/22/5

0/9/15/0

29

30

11

9

Total 37

Total 24

9

PTT left

57

50

4/17/19/10

1/5/2/4

30

29

34

26

Total 50

Total 12

10

PTT right

56

50

3/9/20/7

3/6/4/0

29

30

14

18

Total 39

Total 13

11

PTT right

56

80

0/19/29/4

2/9/13/0

30

29

12

3

Total 53

Total 24

12

PTT right

56

70

0/5/14/6

1/3/8/0

29

30

9

10

Total 25

Total 12

13

PTT left

54

70

3/22/11/8

3/4/9/0

26

28

14

10

Total 44

Total 16

Mean

 

-

56.2

-

-

-

29

29.4

14.1

13

  1. The treatment characteristics include the target and side and the mean and maximum temperatures achieved during treatment. The subjective 3-month follow-up global symptom relief, as well as the pre- and post-FUS UPDRS scores shown here, are also displayed on Figure 4. The pre- and post-operative Mini Mental State Test (MMST) scores as well as Hospital Anxiety and Depression Scores (HADS) on the last four rows show no cognition losses and no emotional worsening for both groups of patients.