Transcranial and pulsed focused ultrasound that activates brain can accelerate remyelination in a mouse model of multiple sclerosis

Table 1 Histological Analysis. Pixel darkness value for ipsilateral (ultrasound) vs contralateral (control) sides, with a higher value marking more myelin, with maximum value equaling 255

Animal Number	ipsilateral	contralateral	difference	% difference^a	interpretation
Group 1
1	30.6	25.7	4.9	19%	More myelin due to ultrasound
2	87.4	66.2	21.2	32%	More myelin due to ultrasound
3	90.9	68.5	22.4	33%	More myelin due to ultrasound
4	75.3	69.7	5.6	8%	More myelin due to ultrasound
Group 2
5	61.2	55.2	6	11%	More myelin due to ultrasound
6	74	75	-1	-1%	More myelin away from ultrasound
7	81.3	70.2	11.1	16%	More myelin due to ultrasound
Mean (All Animals)	71.5+/−7.75	61.5+/− 6.39	10+/− 3.3	16.6+/− 4.7%	Net more myelin due to ultrasound

^a “% difference” = difference between ipsilateral and contralateral myelin values divided by contralateral value then expressed as a percent

ISSN: 2050-5736