Fig. 1

Map of the time course of the experimental procedures. We used two experimental protocols: a ‘short, 5 week’ protocol that tested ultrasound’s effect on demyelination and a ‘long, 15 week’ protocol that tested ultrasound’s effect on remyelination. Both protocols required ultrasound application every day for a week, when appropriate. They differed by the timing of application of Cuprizone chow, ultrasound treatment, MRI imaging and EEG monitoring