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Table 1 High-intensity focused ultrasound for treatment of bone metastases: population results and technical parameters

From: Focused ultrasound for the treatment of bone metastases: effectiveness and feasibility

Population

Results

Technical featuresa

Patients

Age (years)

Sex

Primary tumor

Location

Lesion dimensionsa (mm)

Soft

tissue invasion

Previous Radio-therapy

VAS Before

VAS

D7

VAS

M1

OMEDD Before

OMEDD

M1

Number of Sonications

Mean Acoustic Power

Mean Temperature Monitored

Total Delivered Energy

Treated Volume (Threshold 70°)

N° 1

55

M

Larynx

Tibial diaphysis

39*38*50

Yes

No

8

4

4

30

30

17

90

60

21,400

21.2

N° 2

54

F

Breast

Femoral neck

18*14*28

No

No

9

5

6

30

0

12

50

80

18,353

4.2

N° 3

57

F

Lung

7th Rib

11*7*6

No

No

8

2

0

40

0

15

75

70

12,313

6

N° 4

78

F

Breast

Clavicle

44*29*23

No

Yes

7

3

3

60

10

26

58

75

31,763

27.1

N° 5

74

F

Endometria

Ischio-branch

50*34*33

Yes

No

10

2

2

120

10

15

152

75

73,473

27.1

N° 6

49

M

Kidney

Scapula

15*12*15

No

No

7

0

0

30

30

12

120

80

31,417

22.9

N° 7

89

M

Lung

6th Rib

9*7*5

No

Yes

7

3

2

Non-opiod

Non-opiod

40

40

60

44,244

14.9

N° 8

65

F

Lung

Humerus

32*20*27

No

Yes

10

5

5

160

160

10

100

80

20,057

17.8

N° 9

70

F

Breast

10th rib

19*7*7

No

Yes

6

4

0

300

480

7

70

80

8567

11.4

N° 10

58

F

Lung

Ilio-branch

46*34*24

Yes

Yes

7

3

3

120

120

26

120

80

75,995

44.9

N° 11

64

F

Lung

8th rib

24*13*11

Yes

Yes

8

0

0

1500

400

14

100

80

32,675

30.3

N° 12

50

F

Breast

Iliac bone

51*24*50

Yes

Yes

8

0

0

1600

240

11

220

85

47,423

43.7

N° 13

46

M

Kidney

Tibial diaphysis

29*22*47

Yes

Yes

7

1

1

60

60

9

90

75

16,875

12.4

N° 14

47

M

Lung

4th rib

35*18*32

Yes

No

7

0

0

120

120

6

60

100

8145

13.6

N° 15

60

F

Breast

T5 Transverse apophysis

13*15*20

No

Yes

6

5

2

60

120

12

80

75

20,525

11.6

N° 16

79

M

Prostate

Iliac bone

60*40*36

Yes

No

5

1

0

80

40

9

200

85

32,919

21.1

N° 17

48

M

Lung

Femoral diaphysis

40*26*60

No

No

8

1

4

20

0

16

80

70

24,764

24.2

  1. Soft tissue invasion and lesion dimensions given as long axis (transverse) × short axis (transverse) × craniocaudal dimension (coronal) were measured at pretreatment MRI. Visual Analogic Scale (VAS) before, after 7 days and 1 month were evaluated on a 0–10 scale. Oral Morphine Equivalent Daily Dose (OMEDD) in mg before and after 1 month. Mean acoustic power in Watts. Mean Temperature Monitored in Celsius. Total Delivered Energy in Joules. Treated volume in cubic centimeters using a threshold of 70° in milliliters. aTechnical features were collected after treatment inside the HIFU system