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Table 1 High-intensity focused ultrasound for treatment of bone metastases: population results and technical parameters

From: Focused ultrasound for the treatment of bone metastases: effectiveness and feasibility

Population Results Technical featuresa
Patients Age (years) Sex Primary tumor Location Lesion dimensionsa (mm) Soft
tissue invasion
Previous Radio-therapy VAS Before VAS
D7
VAS
M1
OMEDD Before OMEDD
M1
Number of Sonications Mean Acoustic Power Mean Temperature Monitored Total Delivered Energy Treated Volume (Threshold 70°)
N° 1 55 M Larynx Tibial diaphysis 39*38*50 Yes No 8 4 4 30 30 17 90 60 21,400 21.2
N° 2 54 F Breast Femoral neck 18*14*28 No No 9 5 6 30 0 12 50 80 18,353 4.2
N° 3 57 F Lung 7th Rib 11*7*6 No No 8 2 0 40 0 15 75 70 12,313 6
N° 4 78 F Breast Clavicle 44*29*23 No Yes 7 3 3 60 10 26 58 75 31,763 27.1
N° 5 74 F Endometria Ischio-branch 50*34*33 Yes No 10 2 2 120 10 15 152 75 73,473 27.1
N° 6 49 M Kidney Scapula 15*12*15 No No 7 0 0 30 30 12 120 80 31,417 22.9
N° 7 89 M Lung 6th Rib 9*7*5 No Yes 7 3 2 Non-opiod Non-opiod 40 40 60 44,244 14.9
N° 8 65 F Lung Humerus 32*20*27 No Yes 10 5 5 160 160 10 100 80 20,057 17.8
N° 9 70 F Breast 10th rib 19*7*7 No Yes 6 4 0 300 480 7 70 80 8567 11.4
N° 10 58 F Lung Ilio-branch 46*34*24 Yes Yes 7 3 3 120 120 26 120 80 75,995 44.9
N° 11 64 F Lung 8th rib 24*13*11 Yes Yes 8 0 0 1500 400 14 100 80 32,675 30.3
N° 12 50 F Breast Iliac bone 51*24*50 Yes Yes 8 0 0 1600 240 11 220 85 47,423 43.7
N° 13 46 M Kidney Tibial diaphysis 29*22*47 Yes Yes 7 1 1 60 60 9 90 75 16,875 12.4
N° 14 47 M Lung 4th rib 35*18*32 Yes No 7 0 0 120 120 6 60 100 8145 13.6
N° 15 60 F Breast T5 Transverse apophysis 13*15*20 No Yes 6 5 2 60 120 12 80 75 20,525 11.6
N° 16 79 M Prostate Iliac bone 60*40*36 Yes No 5 1 0 80 40 9 200 85 32,919 21.1
N° 17 48 M Lung Femoral diaphysis 40*26*60 No No 8 1 4 20 0 16 80 70 24,764 24.2
  1. Soft tissue invasion and lesion dimensions given as long axis (transverse) × short axis (transverse) × craniocaudal dimension (coronal) were measured at pretreatment MRI. Visual Analogic Scale (VAS) before, after 7 days and 1 month were evaluated on a 0–10 scale. Oral Morphine Equivalent Daily Dose (OMEDD) in mg before and after 1 month. Mean acoustic power in Watts. Mean Temperature Monitored in Celsius. Total Delivered Energy in Joules. Treated volume in cubic centimeters using a threshold of 70° in milliliters. aTechnical features were collected after treatment inside the HIFU system