Fig. 2 (abstract O52).

Comparison of experimental and simulated growth curves for HCT116 cells treated with different modalities. Left: 2Gy radiation (22000 cells seeded in 24-well plates, surviving fraction S2Gy = 0.43(0.38,0.49)). Right: Combination of 2Gy radiation and heating for 5min at 46°C (300000 cells seeded in 6-well plates, S2Gy+5min,46C = 0.11(0.06,0.19)). Cells were simulated with a mean doubling time of 19.5h. The experimental data points (black circles) are shown, as are the simulated total cell numbers (solid lines), and simulation of the 95% confidence bounds of the surviving fractions used (dashed lines)