TY - JOUR AU - Lyon, Paul C. AU - Griffiths, Lucy F. AU - Lee, Jenni AU - Chung, Daniel AU - Carlisle, Robert AU - Wu, Feng AU - Middleton, Mark R. AU - Gleeson, Fergus V. AU - Coussios, Constantin C. PY - 2017 DA - 2017/11/02 TI - Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours JO - Journal of Therapeutic Ultrasound SP - 28 VL - 5 IS - 1 AB - TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in liver tumours. A key feature of the study is the direct quantification of the doxorubicin concentration before and after ultrasound exposure from tumour biopsies, using high performance liquid chromatography (HPLC). SN - 2050-5736 UR - https://doi.org/10.1186/s40349-017-0104-0 DO - 10.1186/s40349-017-0104-0 ID - Lyon2017 ER -