TY - JOUR AU - Sanghvi, Narendra T. AU - Chen, Wo-Hsing AU - Carlson, Roy AU - Weis, Clint AU - Seip, Ralf AU - Uchida, Toyoaki AU - Marberger, Michael PY - 2017 DA - 2017/09/13 TI - Clinical validation of real-time tissue change monitoring during prostate tissue ablation with high intensity focused ultrasound JO - Journal of Therapeutic Ultrasound SP - 24 VL - 5 IS - 1 AB - The purpose of these clinical studies was to validate a Tissue Change Monitoring (TCM) algorithm in vivo. TCM is a quantitative tool for the real-time assessment of HIFU dose. TCM provides quantitative analysis of the backscatter pulse echo signals (pre and immediately post HIFU) for each individual ablative site, using ultrasonic tissue characterization as a surrogate for monitoring tissue temperature. Real-time analysis generates an energy difference parameter (ΔE in dB) that is proportional to tissue temperature. SN - 2050-5736 UR - https://doi.org/10.1186/s40349-017-0102-2 DO - 10.1186/s40349-017-0102-2 ID - Sanghvi2017 ER -