TY - JOUR AU - Chaplin, Vandiver AU - Caskey, Charles F. PY - 2017 DA - 2017/04/13 TI - Multi-focal HIFU reduces cavitation in mild-hyperthermia JO - Journal of Therapeutic Ultrasound SP - 12 VL - 5 IS - 1 AB - Mild-hyperthermia therapy (40–45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulation, and as a chemotherapy adjuvant. Mechanical damage and loss of cell viability associated with HIFU-induced acoustic cavitation may pose a risk during these treatments or may hinder their success. Here we present a method that achieves mild heating and reduces cavitation by using a multi-focused HIFU beam. We quantify cavitation level and temperature rise in multi-focal sonications and compare it to single-focus sonications at the transducer geometric focus. SN - 2050-5736 UR - https://doi.org/10.1186/s40349-017-0089-8 DO - 10.1186/s40349-017-0089-8 ID - Chaplin2017 ER -