Fig. 3

Demonstration of reformation of beta cells (pink-stained cells) following DUS-guided high MI-targeted delivery of plasmid DNA encoding for cyclin D2/CDK4/GLP1 in high doses (panel d). Panel a demonstrates a normal baboon pancreas. Note the numerous pink-stained cells that are now present. Panel b is UTMD control. Panel c is UTMD with low dose gene therapy. Bottom panel e demonstrates the fraction of beta cells present + US-guided therapies