Fig. 2

Parasternal short axis images and corresponding invasive angiograms of the left anterior descending during intermittent high MI applications of DUS while using very low MI imaging to examine the risk area in between high MI applications. At 20–25 min into therapy, the replenishment of myocardial contrast after a high MI application during the intravenous LEP microbubble infusion is more rapid and angiographic recanalization has occurred (blue arrows)