Journal of Therapeutic Ultrasound

Table 6 Median IVIM parameter values in surrounding muscle and in the tumor VOI, pre- and post-hyperthermia

From: DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia

Surrounding muscle	D _t [10⁻³ mm²/s]				f _p [fraction]				D _p [10⁻³ mm²/s]
Rabbit	Pre	Post		p	Pre	Post		p	Pre	Post		p
1	0.42	0.46		0.670	0.07	0.10		0.026	300	1000	+	<0.001
3	0.32	0.60	+	<0.001	0.16	0.18		0.642	5.6	5.4		0.509
4	0.46	0.55	−	<0.001	0.18	0.16		0.060	6.6	8.2		0.497
Tumor VOI	D _t [10⁻³ mm²/s]				f _p [fraction]				D _p [10⁻³ mm²/s]
Rabbit	Pre	Post		p	Pre	Post		p	Pre	Post		p
1	0.82	1.06	+	<0.001	0.10	0.16	+	<0.001	13.5	5.2	−	<0.001
3	0.40	0.76	+	<0.001	0.19	0.17	−	<0.001	7.6	5.0	−	<0.001
4	1.40	1.82	+	<0.001	0.20	0.16	−	<0.001	4.7	6.0	+	<0.001

Plus signs (+) indicate significant increase after hyperthermia, and minus signs (−) indicate significant decrease after hyperthermia

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