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Table 5 Median DCE parameter values in the surrounding muscle and in the tumor VOI, pre- and post-hyperthermia

From: DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia

Surrounding muscle

K trans [min−1]

v p [fraction]

k ep [min−1]

Rabbit

Pre

Post

 

p

Pre

Post

 

p

Pre

Post

 

p

 1

0.14

0.30

+

<0.001

0.003

0.001

 

0.077

0.65

0.74

 

0.004

 3

0.08

0.20

+

<0.001

0.000

0.000

 

0.021

0.26

0.37

+

<0.001

 4

0.16

0.26

+

<0.001

0.000

0.000

 

0.476

0.43

0.48

 

0.247

 5

0.13

0.27

+

<0.001

0.000

0.000

 

0.817

0.81

0.96

+

<0.001

Tumor VOI

K trans [min−1]

v p [fraction]

k ep [min−1]

Rabbit

Pre

Post

 

p

Pre

Post

 

p

Pre

Post

 

p

 1

0.34

0.68

+

<0.001

0.055

0.085

+

<0.001

0.68

0.80

+

<0.001

 3

0.14

0.34

+

<0.001

0.043

0.024

−

<0.001

0.36

0.41

 

0.006

 4

0.39

0.29

−

<0.001

0.053

0.030

−

<0.001

0.57

0.26

−

<0.001

 5

0.30

0.47

+

<0.001

0.087

0.110

+

<0.001

0.74

0.62

−

<0.001

  1. Plus signs (+) indicate significant increase after hyperthermia, and minus signs (−) indicate significant decrease after hyperthermia