Table 1 High-intensity focused ultrasound (HIFU) ablation studies treating fibroadenomata

Hynynen (2001)

9 (11)

1.9 ± 1.5 cm³ (0.7–6.5)^a

29 (19–38)^b

InSightec (transducer diameter 100 mm and radius curvature 80 mm)

6 (18–48)

Complete necrosis (n = 6), partial necrosis (n = 2), minor necrosis (n = 1) and no response (n = 2)

Oedema, tenderness

–

Tempany (2005)

102

–

–

InSightec (−)

–

–

–

–

Kovatcheva & Boulanger (2014)

42 (51)

3.9 ml (0.3–19.7)^a

32 (16–52)^a

EchoPulse (transducer diameter 60 mm, 3 MHz)

12

Reduction of 33.2 ± 19.1 % at 2 months, 59.2 ± 18.2 % at 6 months and 72.5 ± 16.7 % at 12 months

Skin burn (n = 3), hyperpigmentation (n = 1)

118 (60–255)^a

Cavallo-Marincola (2014)

10

–

26 (18–34)^a

JC HIFU (−)

–

50 % reduction after in maximum diameter after 3 months

Swelling, hardness of area

57.2 (40–100)^a

Hahn (2016)

27

–

–

EchoPulse (transducer diameter 60 mm, 3 MHz)

12

–

–

–

Douek (2016)

50

–

–

EchoPulse (transducer diameter 60 mm, 3 MHz)

12

–

–

Brenin (2016)

20

–

–

EchoPulse (transducer diameter 60 mm, 3 MHz)

12

–

–