Fig. 11

Representative fluorescence images in the targeted and the control (insets) hippocampi when nanodroplets (top) or microbubbles (bottom) and fluorescently labeled 3 kDa dextran were used to mediate BBB opening at frequency of 1.5 MHz, pulse duration of 6.7 ms, pulse repletion frequency of 5 Hz, exposure duration of 5 min, various peak-rarefactional pressures of 0.15 MPa (a and f), 0.225 MPa (b and g), 0.30 MPa (c and h), 0.45 MPa (d and i), and 0.60 MPa (e and j), the scale bar is 1 mm, with courtesy of [27]