Fig. 5
From: Quantitative assessment of damage during MCET: a parametric study in a rodent model
Diagram illustrating a macrolesion as characterized from a stack of histology slices. The heart wall (HW) is depicted in red lines. A cross section of the heart is shown as a histological slice (HS), stained with Evans blue indicating cell necrosis, i.e., microlesions. The ultrasound (US) beam is indicated as a blue line and arrow and was derived from least square fitting of microlesions. Along the beam, the shown green cylindrical disks were characterized from cylindrical volume elements that contain 95 % of the local microlesions. These coaxially stacked disks form a radially symmetric volume, called the macrolesion (ML), which is assumed to correlate with the in situ acoustic field