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Table 1 Bloom–Richardson classification of tumors in sham and treated groups

From: Evaluation of fractionated and repeated sonodynamic therapy by using dual frequency for murine model of breast adenocarcinoma

Group Tumor tubule formation Number of mitoses/10-high-power fields Nuclear grade Total score Bloom–Richardson grade Grade
Sham 2 3 2 7 Moderately differentiated (BR intermediate grade) 2
Dual-frequency sonication + Hp 1 2 3 6 Moderately differentiated (BR intermediate grade) 2
Dual-frequency sonication + Hp (two repetitions) 1 2 3 6 Moderately differentiated (BR intermediate grade) 2
Dual-frequency sonication + Hp (three repetitions) 1 2 3 6 Moderately differentiated (BR intermediate grade) 2
Dual-frequency sonication + Hp (four repetitions) 1 1 2 4 Well differentiated (BR low grade) 1
Dual-frequency sonication + Hp (four fractions) 1 1 2 4 Well differentiated (BR low grade) 1