Figure 4
From: Focused ultrasound-mediated drug delivery to pancreatic cancer in a mouse model
Mouse photographs and whole-body fluorescence images before and after combined PTX-loaded nanodroplet and MRgFUS treatment. Photographs (A, C) and whole-body fluorescence images (B, D) of a mouse before (A, B) and after (C, D) combined treatment with PTX-loaded nanodroplets and MRgFUS. The dashed circles in (B,D) indicate the tumor location. Treatment parameters: MRgFUS was applied 8 h after drug injection; spiral beam pattern (5-mm diameter) shown in Figure 3A; FUS at 3.1 MPa; sonication time of 3 min. The tumor did not recur during a 5-month observation. The former location of the tumor is still slightly visible in D, indicated by the dashed white circle.