From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors
Reference | Animal model | Chemo drug | MB | US | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Type | Dose | Type | Dose | Frequency (MHz) | Pressure (MPa) | Pulse length (ms) | PRF (Hz) | Exposure time of each treatment (s) | Treatment days |
Sonoda et al.[23]  | Mice xenograft eyelid tumor | Bleomycin | 0.003–0.025 mg/mouse | Optison® | 10 μL/mouse | 1 | Intensity: 1 W/cm2 | - | - | 240 | 4 |
Tinkov et al.[38]  | Rat orthotopic pancreas tumor | Dox | 140 μg/rat | Dox-loaded lipid MBs | 3.14 × 109 MB/rat | 1.3 | 1.2 | - | - | 1,200 | 2 |
Sorace et al.[39]  | Mice xenograft breast tumor | Taxol | 0.22 mg/mouse | Definity® | 30 μL/mouse | 1 | 0.1–2.0 | 1,000 | 5 | 300 | 6 |