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Table 3 Summary of UTMD in other tumor therapy studies

From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors

Reference

Animal model

Chemo drug

MB

US

  

Type

Dose

Type

Dose

Frequency (MHz)

Pressure (MPa)

Pulse length (ms)

PRF (Hz)

Exposure time of each treatment (s)

Treatment days

Sonoda et al.[23] 

Mice xenograft eyelid tumor

Bleomycin

0.003–0.025 mg/mouse

Optison®

10 μL/mouse

1

Intensity: 1 W/cm2

-

-

240

4

Tinkov et al.[38] 

Rat orthotopic pancreas tumor

Dox

140 μg/rat

Dox-loaded lipid MBs

3.14 × 109 MB/rat

1.3

1.2

-

-

1,200

2

Sorace et al.[39] 

Mice xenograft breast tumor

Taxol

0.22 mg/mouse

Definity®

30 μL/mouse

1

0.1–2.0

1,000

5

300

6