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Table 3 Summary of UTMD in other tumor therapy studies

From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors

Reference Animal model Chemo drug MB US
   Type Dose Type Dose Frequency (MHz) Pressure (MPa) Pulse length (ms) PRF (Hz) Exposure time of each treatment (s) Treatment days
Sonoda et al.[23]  Mice xenograft eyelid tumor Bleomycin 0.003–0.025 mg/mouse Optison® 10 μL/mouse 1 Intensity: 1 W/cm2 - - 240 4
Tinkov et al.[38]  Rat orthotopic pancreas tumor Dox 140 μg/rat Dox-loaded lipid MBs 3.14 × 109 MB/rat 1.3 1.2 - - 1,200 2
Sorace et al.[39]  Mice xenograft breast tumor Taxol 0.22 mg/mouse Definity® 30 μL/mouse 1 0.1–2.0 1,000 5 300 6