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Table 2 Summary of UTMD in liver tumor therapy studies

From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors

Reference

Animal model

Chemo drug

MB

US

  

Type

Dose

Type

Dose

Frequency (MHz)

Pressure (MPa)

Pulse length (ms)

PRF (Hz)

Exposure time of each treatment (s)

Treatment days

Kang et al.[29]

Rabbit orthotopic liver tumor

Dox

2 mg/rat

Dox-loaded lipid MBs

4.4-6.4 × 109 MBs/rabbit

0.3

Intensity: 2 W/cm2

10 s on

-

360

3

10 s off

Li et al.[28]

Mice xenograft liver tumor

HCPT

4 mg/kg

HCPT-loaded lipid MBs

1.1 × 109 MBs/mice

1

Intensity: 2 W/cm2

10 s on

-

3,600

7

10 s off

Cochran et al.[37]

Rat xenograft liver tumor

Dox

167 μg/rat

Dox-loaded polymer MBs

-

12–5

MI: 0.40–0.45

Doppler mode

1,000

1,200

1