From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors
Reference | Animal model | Chemo drug | MB | US | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Type | Dose | Type | Dose | Frequency (MHz) | Pressure (MPa) | Pulse length (ms) | PRF (Hz) | Exposure time of each treatment (s) | Treatment days |
Kang et al.[29] | Rabbit orthotopic liver tumor | Dox | 2 mg/rat | Dox-loaded lipid MBs | 4.4-6.4 × 109 MBs/rabbit | 0.3 | Intensity: 2 W/cm2 | 10 s on | - | 360 | 3 |
10 s off | |||||||||||
Li et al.[28] | Mice xenograft liver tumor | HCPT | 4 mg/kg | HCPT-loaded lipid MBs | 1.1 × 109 MBs/mice | 1 | Intensity: 2 W/cm2 | 10 s on | - | 3,600 | 7 |
10 s off | |||||||||||
Cochran et al.[37] | Rat xenograft liver tumor | Dox | 167 μg/rat | Dox-loaded polymer MBs | - | 12–5 | MI: 0.40–0.45 | Doppler mode | 1,000 | 1,200 | 1 |