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Table 2 Summary of UTMD in liver tumor therapy studies

From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors

Reference Animal model Chemo drug MB US
   Type Dose Type Dose Frequency (MHz) Pressure (MPa) Pulse length (ms) PRF (Hz) Exposure time of each treatment (s) Treatment days
Kang et al.[29] Rabbit orthotopic liver tumor Dox 2 mg/rat Dox-loaded lipid MBs 4.4-6.4 × 109 MBs/rabbit 0.3 Intensity: 2 W/cm2 10 s on - 360 3
10 s off
Li et al.[28] Mice xenograft liver tumor HCPT 4 mg/kg HCPT-loaded lipid MBs 1.1 × 109 MBs/mice 1 Intensity: 2 W/cm2 10 s on - 3,600 7
10 s off
Cochran et al.[37] Rat xenograft liver tumor Dox 167 μg/rat Dox-loaded polymer MBs - 12–5 MI: 0.40–0.45 Doppler mode 1,000 1,200 1