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Table 1 Summary of UTMD in brain tumor therapy studies

From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors

Reference Animal model Chemo drug MB US
   Type Dose Type Dose Frequency (MHz) Pressure (MPa) Pulse length (ms) PRF (Hz) Exposure time of each treatment (s) Treatment days
Liu et al.[34] Rat xenograft brain glioma BCNU 13.5 mg/kg SonoVue® 2.5 μg/kg 0.4 0.62 10 1 30 1
Ting et al.[35] Rat xenograft brain glioma BCNU - BCNU-loaded MBs - 1 0.7 10 5 60 s per sonication and repeated twice 2
Treat et al.[36] Rat xenograft brain glioma Dox 5.67 mg/kg Definity® 0.01-0.02 ml/kg 1.7 1.2 10 1 60–120 s per sonication and repeated to cover the tumor 1