Table 1 Summary of UTMD in brain tumor therapy studies
From: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors
Reference | Animal model | Chemo drug | MB | US | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Type | Dose | Type | Dose | Frequency (MHz) | Pressure (MPa) | Pulse length (ms) | PRF (Hz) | Exposure time of each treatment (s) | Treatment days |
Liu et al.[34] | Rat xenograft brain glioma | BCNU | 13.5 mg/kg | SonoVue® | 2.5 μg/kg | 0.4 | 0.62 | 10 | 1 | 30 | 1 |
Ting et al.[35] | Rat xenograft brain glioma | BCNU | - | BCNU-loaded MBs | - | 1 | 0.7 | 10 | 5 | 60 s per sonication and repeated twice | 2 |
Treat et al.[36] | Rat xenograft brain glioma | Dox | 5.67 mg/kg | Definity® | 0.01-0.02 ml/kg | 1.7 | 1.2 | 10 | 1 | 60–120 s per sonication and repeated to cover the tumor | 1 |