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  1. Review

    Establishing a clinical service for the treatment of osteoid osteoma using magnetic resonance-guided focused ultrasound: overview and guidelines

    Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive an...

    Michael J. Temple, Adam C. Waspe, Joao G. Amaral, Alessandro Napoli, Suzanne LeBlang, Pejman Ghanouni, Matthew D. Bucknor, Fiona Campbell and James M. Drake

    Journal of Therapeutic Ultrasound 2016 4:16

    Published on: 20 May 2016

  2. Research

    Detection of tissue coagulation by decorrelation of ultrasonic echo signals in cavitation-enhanced high-intensity focused ultrasound treatment

    A noninvasive technique to monitor thermal lesion formation is necessary to ensure the accuracy and safety of high-intensity focused ultrasound (HIFU) treatment. The purpose of this study is to ultrasonically ...

    Shin Yoshizawa, Keiko Matsuura, Ryo Takagi, Mariko Yamamoto and Shin-ichiro Umemura

    Journal of Therapeutic Ultrasound 2016 4:15

    Published on: 14 April 2016

  3. Research

    Assessing heating distribution by therapeutic ultrasound on bone phantoms and in vitro human samples using infrared thermography

    Bioheat models have been proposed to predict heat distribution in multilayered biological tissues after therapeutic ultrasound (TUS) stimulation. However, evidence on its therapeutic benefit is still controver...

    Gabriella Sellani, Dalila Fernandes, Abigail Nahari, Melissa Fabrício de Oliveira, Christiana Valois, Wagner C. A. Pereira and Christiano B. Machado

    Journal of Therapeutic Ultrasound 2016 4:13

    Published on: 5 April 2016

  4. Study protocol

    Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer—a pilot study

    Radiotherapy is a critical component of the multidisciplinary management of cancers of the head and neck. It may comprise the primary curative treatment modality or is used in an adjuvant setting to improve lo...

    Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen and Danny Enepekides

    Journal of Therapeutic Ultrasound 2016 4:12

    Published on: 2 April 2016

  5. Research

    Simulation of high-intensity focused ultrasound lesions in presence of boiling

    The lesions induced by high-intensity focused ultrasound (HIFU) thermal ablations are particularly difficult to simulate due to the complexity of the involved phenomena. In particular, boiling has a strong inf...

    Anthony Grisey, Sylvain Yon, Véronique Letort and Pauline Lafitte

    Journal of Therapeutic Ultrasound 2016 4:11

    Published on: 31 March 2016

  6. Research

    In-vitro cell treatment with focused shockwaves—influence of the experimental setup on the sound field and biological reaction

    To improve understanding of shockwave therapy mechanisms, in vitro experiments are conducted and the correlation between cell reaction and shockwave parameters like the maximum pressure or energy density is st...

    Kristin Dietz-Laursonn, Rainer Beckmann, Siegfried Ginter, Klaus Radermacher and Matías de la Fuente

    Journal of Therapeutic Ultrasound 2016 4:10

    Published on: 29 March 2016

  7. Research

    DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia

    The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ult...

    Mie K. Lam, Chris Oerlemans, Martijn Froeling, Roel Deckers, Angelique D. Barten-Van Rijbroek, Max A. Viergever, Chrit T. W. Moonen, Clemens Bos and Lambertus W. Bartels

    Journal of Therapeutic Ultrasound 2016 4:9

    Published on: 15 March 2016

  8. Research

    Equipment, measurement and dose—a survey for therapeutic ultrasound

    Dosimetry for Ultrasound Therapy (DUTy) is a large international project which addresses the development of a metrological infrastructure for the determination of ultrasound exposure and dose to tissue.

    Adam Shaw, Eleanor Martin, Julian Haller and Gail ter Haar

    Journal of Therapeutic Ultrasound 2016 4:7

    Published on: 2 March 2016

  9. Review

    Towards use of MRI-guided ultrasound for treating cerebral vasospasm

    Cerebral vasospasm is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH), causing delayed neurological deficits in as many as one third of cases. Existing therapy targets i...

    Robert H. Bonow, John R. Silber, Dieter R. Enzmann, Norman J. Beauchamp, Richard G. Ellenbogen and Pierre D. Mourad

    Journal of Therapeutic Ultrasound 2016 4:6

    Published on: 29 February 2016

  10. Research

    Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

    Already in the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat pati...

    Marc N. Gallay, David Moser, Franziska Rossi, Payam Pourtehrani, Anouk E. Magara, Milek Kowalski, Alexander Arnold and Daniel Jeanmonod

    Journal of Therapeutic Ultrasound 2016 4:5

    Published on: 13 February 2016

  11. Research

    Renal sympathetic denervation using MR-guided high-intensity focused ultrasound in a porcine model

    Initial catheter-based renal sympathetic denervation (RSD) studies demonstrated promising results in showing a significant reduction of blood pressure, while recent data were less successful. As an alternative...

    Matthias Koopmann, Jill Shea, Eugene Kholmovski, Joshua de Bever, Emilee Minalga, Matthew Holbrook, Robb Merrill, J. Rock Hadley, Theophilus Owan, Mohamed E. Salama, Nassir F. Marrouche and Allison Payne

    Journal of Therapeutic Ultrasound 2016 4:3

    Published on: 3 February 2016

  12. Research

    Minimizing eddy currents induced in the ground plane of a large phased-array ultrasound applicator for echo-planar imaging-based MR thermometry

    The study aims to investigate different ground plane segmentation designs of an ultrasound transducer to reduce gradient field induced eddy currents and the associated geometric distortion and temperature map ...

    Silke M. Lechner-Greite, Nicolas Hehn, Beat Werner, Eyal Zadicario, Matthew Tarasek and Desmond Yeo

    Journal of Therapeutic Ultrasound 2016 4:4

    Published on: 3 February 2016

  13. Review

    A review of ablative techniques in the treatment of breast fibroadenomata

    Breast fibroadenomata (FAD) are benign lesions which occur in about 10 % of all women. Diagnosis is made by triple assessment (physical examination, imaging and/or histopathology/cytology). For a definitive di...

    Mirjam C. L. Peek, Muneer Ahmed, Sarah E. Pinder and Michael Douek

    Journal of Therapeutic Ultrasound 2016 4:1

    Published on: 19 January 2016

  14. Case study

    Non-invasive magnetic resonance-guided high intensity focused ultrasound ablation of a vascular malformation in the lower extremity: a case report

    Therapy of choice for symptomatic vascular malformations consists of surgery, sclerotherapy, or embolization. However, these techniques are invasive with possible complications and require hospitalization. We ...

    Johanna M. M. van Breugel, Robbert J. Nijenhuis, Mario G. Ries, Raechel J. Toorop, Evert-Jan P. A. Vonken, Joost W. Wijlemans and Maurice A. A. J. van den Bosch

    Journal of Therapeutic Ultrasound 2015 3:23

    Published on: 30 December 2015

  15. Research

    Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents

    Focused ultrasound combined with microbubble injection is capable of locally and transiently enhancing the permeability of the blood-brain barrier (BBB). Magnetic resonance imaging (MRI) guidance enables to pl...

    Rémi Magnin, Fabien Rabusseau, Frédéric Salabartan, Sébastien Mériaux, Jean-François Aubry, Denis Le Bihan, Erik Dumont and Benoit Larrat

    Journal of Therapeutic Ultrasound 2015 3:22

    Published on: 24 December 2015

  16. Case study

    Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report

    High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurre...

    M. Abel, H. Ahmed, E. Leen, E. Park, M. Chen, H. Wasan, P. Price, L. Monzon, W. Gedroyc and P. Abel

    Journal of Therapeutic Ultrasound 2015 3:21

    Published on: 18 December 2015

  17. Research

    Sonoporation efficacy on SiHa cells in vitro at raised bath temperatures—experimental validation of a prototype sonoporation device

    A device was devised which aimed to reduce the time and expertise required to perform sonoporation on adherent cell cultures. This prototype device was used to examine the superficial effect of bath temperatur...

    Jonathan Kivinen, Melissa Togtema, Gregor Mulzer, Joshua Choi, Ingeborg Zehbe, Laura Curiel and Samuel Pichardo

    Journal of Therapeutic Ultrasound 2015 3:19

    Published on: 6 November 2015

  18. Research

    Quantitative assessment of damage during MCET: a parametric study in a rodent model

    Myocardial cavitation-enabled therapy (MCET) has been proposed as a means to achieve minimally invasive myocardial reduction using ultrasound to produce scattered microlesions by cavitating contrast agent micr...

    Yiying I. Zhu, Douglas L. Miller, Chunyan Dou, Xiaofang Lu and Oliver D. Kripfgans

    Journal of Therapeutic Ultrasound 2015 3:18

    Published on: 16 October 2015

  19. Research

    Deep Bleeder Acoustic Coagulation (DBAC)—part II: in vivo testing of a research prototype system

    Deep Bleeder Acoustic Coagulation (DBAC) is an ultrasound image-guided high-intensity focused ultrasound (HIFU) method proposed to automatically detect and localize (D&L) and treat deep, bleeding, combat wound...

    K. Michael Sekins, Stephen R. Barnes, Liexiang Fan, Jerry D. Hopple, Stephen J. Hsu, John Kook, Chi-Yin Lee, Caroline Maleke, Xiaozheng (Jenny) Zeng, Romain Moreau-Gobard, Alexis Ahiekpor-Dravi, Gareth Funka-Lea, John Eaton, Keith Wong, Scott Keneman, Stuart B. Mitchell…

    Journal of Therapeutic Ultrasound 2015 3:17

    Published on: 24 September 2015

  20. Research

    Deep bleeder acoustic coagulation (DBAC)—Part I: development and in vitro testing of a research prototype cuff system

    Bleeding from limb injuries is a leading cause of death on the battlefield, with deep wounds being least accessible. High-intensity focused ultrasound (HIFU) has been shown capable of coagulation of bleeding (...

    K. Michael Sekins, Stephen R. Barnes, Liexiang Fan, Jerry D. Hopple, Stephen J. Hsu, John Kook, Chi-Yin Lee, Caroline Maleke, A R Ramachandran, Xiaozheng (Jenny) Zeng, Romain Moreau-Gobard, Alexis Ahiekpor-Dravi, Gareth Funka-Lea, Stuart B. Mitchell, Barbrina Dunmire, John C. Kucewicz…

    Journal of Therapeutic Ultrasound 2015 3:16

    Published on: 18 September 2015

  21. Research

    T2-based temperature monitoring in abdominal fat during MR-guided focused ultrasound treatment of patients with uterine fibroids

    Near-field heating is a potential problem in focused ultrasound treatments, as it can result in thermal injury to skin, subcutaneous fat, and other tissues. Our goals were to determine if T2-based temperature ...

    Eugene Ozhinsky, Maureen P. Kohi, Pejman Ghanouni and Viola Rieke

    Journal of Therapeutic Ultrasound 2015 3:15

    Published on: 11 September 2015

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