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Table 2 The treatment characteristics include: ETRS, drawing of spirals, handwriting, gait instability, HADS, MoCA and hand function subscores (HF16 and HF32) at baseline (B), 2 days after the procedure (2d), 3 months (3m), and the last follow-up (F) ranging from 1 year (1y) to 2 years (2y) and in percent of improvement (%i)

From: Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

  

ETRS (B/3m/1y)

Spiral (B/F/%i)

Handwriting (B/F/%i)

Gait instability (B/2d/F)

HADS (B/2d)

MoCA (B/2d)

HF32 (B/2d)

HF16 (B/2d/%i/3m/%i/1y/%i)

HF16 (2d/1y after the second side/%i)

Group 1

1

77/–/52

4/1/75

4/0/100

0/0/0

14/8

29/30

32/20

16/4/75/8/50/9/44

2.5/4/75

2

65/41.5/18

4/0.5/87.5

3/0.5/83

1.5/1.5/2.5

10/22

29/29

31/19

16/3/81/4/78/4/75

3.5/2/88

3

55/53/56

4/3/25

4/3/25

1/1/0.5

5/7

25/26

29/21

13/5/62/13/0/13/0

–/–/–

4

84/61/–

4/4/0

4/3/25

3/3/2

22/21

26/27

32/24

16/8/50/11/31/–/–

–/–/–

5

70/–/–

4/1/75

3/0/100

1.5/1.5/–

16/–

25/25

32/17

16/1/94/5/69/–/–

–/–/–

6

77/–/–

4/4/0

3.5/3.5/0

2/2/–

–/–

24/26

30/24

14/9/36/15/0/–/–

–/–/–

7

70/68/–

4/1.5/62.5

4/3/25

2.5/2.5/3

15/9

26/29

32/23

16/7/56/7/56/–/–

–/–/–

Mean

 

71.1/55.9/42

4/2.1/46.4

3.6/1.9/51.2

1.6/1.6/1.6

13.7/13.4

26.3/27.4

31.1/21.1

15.3/5.3/64.8/9/40.6/8.7/39.6

3/3/81.3

SD±

 

9.4/11.4/20.9

0/1.5/–

0.5/1.6/–

1/1/1.3

5.8/7.4

2/1.9

1.2/2.7

1.3/2.9/–/4.1/–/4.5/–

0.7/1.4/–

Group 2

8

61/–/–

2/0/100

4/0/100

0/0/0

7/–

28/30

24/14

10/0/100/0/100/0/100

 

9

49/20/16

3/1/66.7

4/2.5/38

0/0/0

3/1

28/28

17/4

13/1/92/4/69/2/85

 

10

53/20/22

2.5/0/100

1/0/100

0/0/0

3/2

28/30

18/11

7/0/100/0/100/1/86

 

11

67/–/37

3/0.5/83

2.5/0/100

0/0/0.5

7/5

29/29

27/3

14/1/93/3/79/3/79

 

12

61/–/–

3/0/100

2/0/100

0/0/0

12/–

30/30

25/15

12/2/83/0/100/–/–

 

13

45/–/11

2.5/0/100

2/0/100

0.5/1/0.5

8/6

29/29

17/4

7/0/100/0/100/0/100

 

14

50/25/11.5

3.5/0/100

4/1.5/63

2/2.5/2

22/18

20/25

21/10

12/1/92/1/92/0/100

 

15

46/–/–

4/0/100

2/0/100

0/0/0

17/–

27/29

17/4

13/0/100/0/100/–/–

 

16

38/–/11.5

3/0.5/83

2.5/0/100

0/1/0

2/1

29/30

16.5/4

12.5/0/100/1/92/1/92

 

17

56/–/–

4/0/100

3/0/100

3/2.5/–

16/–

25/29

28/13

16/1/94/1/94/–/–

 

18

48/12/10

3/0/100

3/0/100

0/0/0

6/11

28/29

20/8

12/0/100/0/100/0/100

 

19

36/18/–

3/0/100

3/0/100

1/1/1

16/17

27/27

12/4

5/0/100/0/100/–/–

 

20

46/23.5/–

2/1/50

2/0/100

0/1/0

12/6

25/27

18/11

8/1/88/2.5/69/–/–

 

21

56/–/–

3/1/67

2.5/0/100

0/0/0

–/–

27/28

22/9

12/2/83/3.5/71/3.5/71

 

Mean

 

50.9/19.8/17

3/0.3/89 %

2.7/0.3/93 %

0.5/0.6/0.3

10.1/7.4

27.1/28.6

20.2/8.1

11/0.6/95 %/1.1/90 %/1.2/90 %

 

SD±

 

8.8/4.6/9.8

0.6/0.4/–

0.9/0.8/–

0.9/0.9/0.6

6.3/6.5

2.5/1.5

4.6/4.3

3.1/0.7/–/1.5/–/1.4/–

 
  1. MoCA scores pre- and post-procedure show no cognition losses. HADS scores show stable toward improved emotional state (higher scores indicating more emotional distress)