Volume 3 Supplement 1
The relationship of T2WI signal intensity of uterine fibroids and the temperature curve in MR-guided high-intensity focused ultrasound (HIFU) ablation
© Liu et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
MR guided high-intensity focused ultrasound (HIFU) ablation is increasingly being used worldwide to treat symptomatic uterine fibroids because of its excellent therapeutic efficacy in controlling symptoms and its excellent safety record. High signal intensity on T2WI MR images of fibroids is firstly considered a factor that induces poor ablation outcomes. Nevertheless, to our HIFU clinical practice, signal intensity on T2WI MR images is not that accurate for determining whether the fibroids are hyper-perfusion or hypo-perfusion because signal intensity on T2WI is just a relative and subjective parameter, which cannot quantify perfusion. It is demonstrated that the temperature curve (i.e. temperature change as a function of time) during HIFU treatments is a relatively accurate manifestation of fibroids’ reaction to sonication. The purpose of this study was to retrospectively study the relationship of T2WI signal intensity of uterine fibroids and the temperature curve in MR guided HIFU.
Results and conclusions
Parameters of the temperature curves of 3 types of fibroids
Types of fibroids
Time to peak(s)
AUC(°C • s)
It had a less effective therapy (AUC: 2036.5±361.5°C• s). The temperature curve of type 3 fibroids ascended slowly (heating slope: 0.52°C/s, time to peak: 20.6s), descended most slowly (decay slope: 0.39°C/s) and had the least effective therapy (AUC: 1597.2°C• s, heating time: 12.9s).
The efficacy of HIFU treatments based on temperature curve correlates well with the T2WI signal intensity of uterine fibroids.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.