Volume 3 Supplement 1

Current and Future Applications of Focused Ultrasound 2014. 4th International Symposium: abstracts

Open Access

Volumetric MR-guided high-intensity focused ultrasound with direct skin cooling for the treatment of symptomatic uterine fibroids: proof of concept study

  • Marlijne Ikink1,
  • Johanna van Breugel1,
  • Gerald Schubert2,
  • Robbert Nijenhuis1,
  • Lambertus W Bartels1,
  • Chrit Moonen1 and
  • Maurice van den Bosch1
Journal of Therapeutic Ultrasound20153(Suppl 1):O92

DOI: 10.1186/2050-5736-3-S1-O92

Published: 30 June 2015

Background/introduction

To prospectively assess the safety and technical feasibility of volumetric magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablation with direct skin cooling (DISC) during treatment of uterine fibroids.

Methods

In this proof-of-concept study, eight patients were selected for clinical MR-HIFU ablation of uterine fibroids with use of an additional DISC device to maintain a constant temperature (T≈20°C) at the interface between the HIFU table-top and the patients’ skin (Figure 1). Technical feasibility was determined by verification of successful completion of MR-HIFU ablation. Contrast-enhanced T1-weighted MRI was used to measure the treatment effect (non-perfused volume (NPV) ratio). Safety was evaluated by recording of adverse events (AEs) and their relation to the investigational DISC device within 30 days’ follow-up.
https://static-content.springer.com/image/art%3A10.1186%2F2050-5736-3-S1-O92/MediaObjects/40349_2015_Article_152_Fig1_HTML.jpg

Figure 1

Results and conclusions

Results: All MR-HIFU treatments were successfully completed in an outpatient setting. The median NPV-ratio was 0.56 (IQR[0.27-0.72]). Immediately after treatment, two patients experienced coldness related discomfort which resolved the same day. No serious AEs were reported within 30-days’ follow-up. No skin burns, cold injuries or subcutaneous edema were observed in patients treated with the DISC device. Conclusion: This study showed that it is technically feasible and safe to complete a volumetric MR-HIFU ablation with DISC. This technique may further reduce the risk of thermal injury to the abdominal wall during MR-HIFU ablation of uterine fibroids.

Authors’ Affiliations

(1)
University Medical Center Utrecht
(2)
Philips Healthcare

Copyright

© Ikink et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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