Volume 3 Supplement 1
Dual echo gradient echo imaging for simultaneous thermal mapping in cortical bone and soft tissue
© Ramsay et al; licensee BioMed Central Ltd. 2015
Published: 30 June 2015
MRI-guided high-intensity focused ultrasound (MR-HIFU) therapy can relieve pain associated with metastatic and benign bone tumours in patients who fail to respond to conventional radiation therapy. However, since existing MR-thermometry techniques do not provide temperature information within the bone, HIFU exposures in bone are currently monitored using temperature changes in adjacent soft tissues. In this study, a standard dual echo spoiled gradient echo (SPGR) sequence is proposed to monitor thermal effects in both bone and soft tissue simultaneously. Magnitude signal changes at the shorter TE (~1ms) reflect thermal changes in cortical bone, while phase changes at the longer TE (~10ms) allow conventional PRF thermometry in surrounding tissues.
Results and conclusions
As shown in the Figure, local cortical bone temperature changes were well-correlated temporally (1B) and spatially (1C) with changes in signal magnitude at short (~1ms) echo times, while temperature in the gel could be measured via changes in the voxel phase at long (10ms) echo times (1D). These results demonstrate a simple method for monitoring thermal changes simultaneously in cortical bone and soft tissue using a dual echo gradient echo sequence. The technique can be easily translated onto existing MR imaging systems thus improving the safety of MR HIFU treatments.
This research was supported by the NIH.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.